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18Fdg-Labeled Likkpf: A Pet Tracer for Apoptosis Imaging Publisher



Khoshbakht S1 ; Beiki D2 ; Geramifar P2 ; Kobarfard F3 ; Sabzevari O4 ; Amini M5 ; Shahhosseini S6
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Authors Affiliations
  1. 1. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmaceutical Chemistry, School of Pharmacy, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Toxicology & Pharmacology, Faculty of Pharmacy, and Toxicology and Poisoning Research Centre, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medicinal Chemistry, Faculty of Pharmacy, and Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Pharmaceutical Chemistry, School of Pharmacy, and PET/CT Unit, Ferdous Nuclear Medicine Center, Dr Masih Daneshvari Hospital, Shahid Behesti University of Medical Sciences, Vali-e Asr Ave., Niayesh Junction, P.O. Box 14155-6153, Tehran, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2016


Abstract

One of the early biochemical changes of apoptotic cells is exposure of phosphatidylserine on the external surface of the plasma membrane. The aim of current study is targeting Phosphatidyl serine (PS) using radiolabeled LIKKPF, which was functionalized with HYNIC and aminooxy, radiolabeled with 18FDG and assessed in vitro and in vivo. Results showed LIKKPF has less affinity to PS compared to original phage peptide, but high enough for specific binding to apoptotic cells. It is concluded the low affinity of radiolabeled LIKKPF might be attributed to hydrophobicity of peptide, therefor peptides used in future studies should be more hydrophobic compared to LIKKPF. © 2016, Akademiai Kiado, Budapest, Hungary.
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