Leishmania Tropica Infected Human Lesions: Whole Genome Transcription Profiling

Leishmania Tropica Infected Human Lesions: Whole Genome Transcription Profiling Publisher Pubmed

Masoudzadeh N¹ ; Mizbani A² ; Taslimi Y¹ ; Mashayekhi V³ ; Mortazavi H⁴ ; Sadeghipour P¹ ; Ardekani HM¹ ; Rafati S¹

Show Affiliations

1. Immunotherpy and Leishmania Vaccine Research Dept., Pasteur Institute of Iran, Tehran, Iran
2. Zurich, Switzerland
3. Cutaneous Leishmaniasis Research Center, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4. Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Acta Tropica Published:2017

Abstract

Leishmania (L.) tropica is the main causative agent of anthroponotic cutaneous leishmaniasis (CL) in Iran. Defining the host inflammatory response in the L. tropica lesions are crucial for the development of new treatment modalities. High-throughput RNA sequencing provides a powerful method for characterization of the human gene expression profile in L. tropica lesions. Comparing the transcription profile of the L. tropica skin lesions with normal skin identified over 5000 differentially regulated genes. Gene set enrichment analysis indicated significant activation of key immunological pathways related to antigen processing and presentation. In addition, we observed a substantial upregulation of immunoglobulin genes in lesion samples, highlighting the remarkable involvement of B cells in the infection site. To our knowledge, this study is the first report to build a comprehensive picture of transcriptome changes in acute human skin lesions during infection by L. tropica. © 2017 Elsevier B.V.

Related Docs

View other Related Docs

1. Immune Response in Cutaneous Leishmaniasis Patients With Healing Vs. Non-Healing Lesions, Iranian Journal of Microbiology (2020)

2. Potential Biomarkers of Immune Protection in Human Leishmaniasis, Medical Microbiology and Immunology (2021)

3. A Novel Non-Invasive Diagnostic Sampling Technique for Cutaneous Leishmaniasis, PLoS Neglected Tropical Diseases (2017)

4. The Geographical Distribution of Human Cutaneous and Visceral Leishmania Species Identified by Molecular Methods in Iran: A Systematic Review With Meta-Analysis, Frontiers in Public Health (2021)

5. Genetic Diversity and Phylogenetic Analysis of the Iranian Leishmania Parasites Based on Hsp70 Gene Pcr-Rflp and Sequence Analysis, Korean Journal of Parasitology (2017)

6. A Pleiotropic Recurrent Dominant Itpr3 Variant Causes a Complex Multisystemic Disease, Science Advances (2024)

7. Hrm–Pcr Is an Accurate and Sensitive Technique for the Diagnosis of Cutaneous Leishmaniasis As Compared With Conventional Pcr, Acta Parasitologica (2020)

8. Meta-Analysis of Gene Expression Profiles in Acute Promyelocytic Leukemia Reveals Involved Pathways, International Journal of Hematology-Oncology and Stem Cell Research (2017)

Experts (# of related papers)

View all Related Experts

Homa Hajjaran (3)

Seyed Naser Emadi (2)

Style	Citing Format
MLA	Masoudzadeh N, et al.. "Leishmania Tropica Infected Human Lesions: Whole Genome Transcription Profiling." Acta Tropica, vol. 176, no. , 2017, pp. 236-241.
APA	Masoudzadeh N, Mizbani A, Taslimi Y, Mashayekhi V, Mortazavi H, Sadeghipour P, Ardekani HM, Rafati S (2017). Leishmania Tropica Infected Human Lesions: Whole Genome Transcription Profiling. Acta Tropica, 176(), 236-241.
Chicago	Masoudzadeh N, Mizbani A, Taslimi Y, Mashayekhi V, Mortazavi H, Sadeghipour P, Ardekani HM, Rafati S. "Leishmania Tropica Infected Human Lesions: Whole Genome Transcription Profiling." Acta Tropica 176, no. (2017): 236-241.
Harvard	Masoudzadeh N et al. (2017) 'Leishmania Tropica Infected Human Lesions: Whole Genome Transcription Profiling', Acta Tropica, 176(), pp. 236-241.
Vancouver	Masoudzadeh N, Mizbani A, Taslimi Y, Mashayekhi V, Mortazavi H, Sadeghipour P, et al.. Leishmania Tropica Infected Human Lesions: Whole Genome Transcription Profiling. Acta Tropica. 2017;176():236-241.
BibTex	@article{ author = {Masoudzadeh N and Mizbani A and Taslimi Y and Mashayekhi V and Mortazavi H and Sadeghipour P and Ardekani HM and Rafati S}, title = {Leishmania Tropica Infected Human Lesions: Whole Genome Transcription Profiling}, journal = {Acta Tropica}, volume = {176}, number = {}, pages = {236-241}, year = {2017} }
RIS	TY - JOUR AU - Masoudzadeh N AU - Mizbani A AU - Taslimi Y AU - Mashayekhi V AU - Mortazavi H AU - Sadeghipour P AU - Ardekani HM AU - Rafati S TI - Leishmania Tropica Infected Human Lesions: Whole Genome Transcription Profiling JO - Acta Tropica VL - 176 IS - SP - 236 EP - 241 PY - 2017 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract