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Trichilemmal Carcinoma in an Iranian Patient: Reporting a Rare Skin Tumor Publisher



Esmati E1 ; Rajabpour MV1, 2 ; Shirkhoda M2 ; Soleimani V3 ; Garousi M4
Authors
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Authors Affiliations
  1. 1. Radiation Oncology Research Center (RORC), Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Pathology Department, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Radiation Oncology Department, Iran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Dermatology Published:2021


Abstract

Trichilemmal carcinoma is a rare tumor of the outer sheath cells of hair follicles. These tumors occur on the sun-exposed skin of the elderly in the majority of cases. The gross tumor demonstrates exophytic, polypoid, ulcerative, or nodular lesions with or without bleeding. Histopathologically, it is characterized by an anastomosing trabecular, diffuse, or lobular growth pattern with clear keratinization. A critical differential diagnosis is squamous cell carcinoma (SCC), where the prognosis of trichilemmal carcinoma is far better than SCC. Surgery is a significant and effective treatment for trichilemmal carcinoma cases, and recurrence after complete surgical resection with a negative margin is uncommon. Trichilemmal carcinoma is considered a low-grade tumor with low metastatic potential. This paper reports a 48-year-old Iranian male with trichilemmal carcinoma of the scalp treated with surgery, having no recurrence after three years of follow-up. The role of other treatment modalities like radiation, local therapy, and systemic therapy are also discussed. Iranian Journal of Dermatology© 2021 Iranian Society of Dermatology.