Dysregulation of Nf-Κb-Associated Lncrnas in Autism Spectrum Disorder

Dysregulation of Nf-Κb-Associated Lncrnas in Autism Spectrum Disorder Publisher

Honarmand Tamizkar K¹ ; Badrlou E¹ ; Aslani T² ; Brand S^{3, 4, 5, 6, 7} ; Arsangjang S⁸ ; Ghafourifard S⁹ ; Taheri M¹⁰

Show Affiliations

1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
3. Center for Affective, Stress and Sleep Research, Psychiatric Clinics, University of Basel, Basel, Switzerland
4. Division of Sport Science and Psychosocial Health, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland
5. Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
6. Sleep Disorder Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
7. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
8. Cancer Gene therapy Research Center, Zanjan University of Medical Science, Zanjan, Iran
9. Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
10. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Frontiers in Molecular Neuroscience Published:2021

Abstract

Autism spectrum disorder (ASD) is a long-standing neurodevelopmental condition with prominent effects on social behavior of affected children. This disorder has been linked with neuroinflammatory responses. NF-κB has been shown to affect these responses in the orbitofrontal cortex of patients with ASD, thus being implicated in the pathogenesis of ASD. We measured expression of some NF-κB-associated lncRNAs and mRNAs (DILC, ANRIL, PACER, CHAST, ADINR, DICER1-AS1, HNF1A-AS1, NKILA, ATG5 and CEBPA) in the peripheral blood of ASD kids vs. healthy children. Expression quantities of ADINR, ANRIL, DILC, NKILA and CHAST were meaningfully higher in ASD cases compared with healthy kids (Posterior Beta = 1.402, P value < 0.0001; Posterior Beta = 2.959, P value < 0.0001; Posterior Beta = 0.882, P value = 0.012; Posterior Beta = 1.461, P value < 0.0001; Posterior Beta = 0.541, P value = 0.043, respectively). The Bonferroni corrected P values for these lncRNAs remained significant except for CHAST and DILC. Expression levels of other genes were not considerably different between cases and controls. Expressions of ATG5, DICER-AS1 and DILC were correlated with age of ASD patients (P < 0.0001). Among ASD cases, the most robust correlation has been detected between ADINR and NKILA (r = 0.87, P < 0.0001). Expression of none of genes has been correlated with age of healthy children. Among this group of children, expression levels of ADINR and CHAST were robustly correlated (r = 0.83, P < 0.0001). ANRIL had the greatest AUC value (AUC = 0.857), thus the best diagnostic power among the assessed genes. NKILA ranked the second position in this regard (AUC = 0.757). Thus, NF-κB-associated lncRNAs might partake in the pathogenesis of ASD. © Copyright © 2021 Honarmand Tamizkar, Badrlou, Aslani, Brand, Arsang-Jang, Ghafouri-Fard and Taheri.

Experts (# of related papers)

Nima Rezaei (1)

Style	Citing Format
MLA	Honarmand Tamizkar K, et al.. "Dysregulation of Nf-Κb-Associated Lncrnas in Autism Spectrum Disorder." Frontiers in Molecular Neuroscience, vol. 14, no. , 2021, pp. -.
APA	Honarmand Tamizkar K, Badrlou E, Aslani T, Brand S, Arsangjang S, Ghafourifard S, Taheri M (2021). Dysregulation of Nf-Κb-Associated Lncrnas in Autism Spectrum Disorder. Frontiers in Molecular Neuroscience, 14(), -.
Chicago	Honarmand Tamizkar K, Badrlou E, Aslani T, Brand S, Arsangjang S, Ghafourifard S, Taheri M. "Dysregulation of Nf-Κb-Associated Lncrnas in Autism Spectrum Disorder." Frontiers in Molecular Neuroscience 14, no. (2021): -.
Harvard	Honarmand Tamizkar K et al. (2021) 'Dysregulation of Nf-Κb-Associated Lncrnas in Autism Spectrum Disorder', Frontiers in Molecular Neuroscience, 14(), pp. -.
Vancouver	Honarmand Tamizkar K, Badrlou E, Aslani T, Brand S, Arsangjang S, Ghafourifard S, et al.. Dysregulation of Nf-Κb-Associated Lncrnas in Autism Spectrum Disorder. Frontiers in Molecular Neuroscience. 2021;14():-.
BibTex	@article{ author = {Honarmand Tamizkar K and Badrlou E and Aslani T and Brand S and Arsangjang S and Ghafourifard S and Taheri M}, title = {Dysregulation of Nf-Κb-Associated Lncrnas in Autism Spectrum Disorder}, journal = {Frontiers in Molecular Neuroscience}, volume = {14}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Honarmand Tamizkar K AU - Badrlou E AU - Aslani T AU - Brand S AU - Arsangjang S AU - Ghafourifard S AU - Taheri M TI - Dysregulation of Nf-Κb-Associated Lncrnas in Autism Spectrum Disorder JO - Frontiers in Molecular Neuroscience VL - 14 IS - SP - EP - PY - 2021 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract