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Uncovering Systemic Lupus Erythematosus Candidate Proteomic Biomarkers: A Bioinformatics Approach Publisher



Azodi MZ1 ; Tavirani MR2 ; Nejad MR3 ; Arjmand B4 ; Razzaghi M5
Authors
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Authors Affiliations
  1. 1. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Research Institute for Gastroenterology and Liver Diseases, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Cellular and Molecular Anesthesia Published:2022


Abstract

Background: Molecular analysis of different types of disease could be helpful to understand the mechanisms of the related abnormal functions at that level of disorder. Lupus is not an exception; by using protein-protein interaction network analysis, it is possible to investigate the molecular basis and malfunctions in this kind of disease. Materials and Methods: Thirteen proteins were explored for interaction purposes, and some 12 central proteins were obtained via Cytoscape analysis. Results: Among these proteins, three proteins were from the differentially expressed proteins or reported biomarkers of lupus. These proteins include Haptoglobin (Hp), Apolipoprotein C-III (APOC3), and Apolipoprotein A-I (APOA1). Conclusion: It can be concluded that the biological processes of the central proteins could be part of Lupus's underlying mechanisms. Finally, validation studies are proposed by this current evaluation of the introduced panel of hub biomarkers. © 2022 by the authors.
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