Mif 173 G>C Variation Was Associated With Depressive Disorder in Type 2 Diabetes in an Iranian Population

Mif 173 G>C Variation Was Associated With Depressive Disorder in Type 2 Diabetes in an Iranian Population Publisher Pubmed

Hamidi AK¹ ; Arzaghi SM³ ; Qorbani M² ; Khatami F⁷ ; Ebrahimi M⁴ ; Bandarian F⁵ ; Enayati S¹ ; Amoli MM^{1, 6}

Show Affiliations

1. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
3. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Internal Medicine Department, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
5. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
7. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Psychoneuroendocrinology Published:2019

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a continuous metabolic disease linked with increased rate of mortality and morbidity. High levels of glucose can damage organs including kidneys, eyes, and the nervous system. Individuals with T2DM have a high prevalence of major depression. One possible question we aimed to address was the extent of co-occurrence of diabetes and depression resulting from correlated genetic risk factors. Objectives: The current study aimed to investigate the possible associations between the macrophage migration inhibitory factor (MIF) functional variant and the risk of developing depression in T2DM patients. Patients and methods: The study groups consisted of 120 patients with T2DM and comorbid depression and 120 patients with T2DM, without depression, who were recruited from the same region. Genotyping of the MIF -173 G > C (rs755622) variant was performed using Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP). In addition, the level of MIF expression was comparatively evaluated in both groups by quantitative real-time PCR. Result: The data showed that the presence of C allele (GC + CC vs. GG) might predispose females to depression in patients with T2DM. In addition, patients with T2DM carrying at least one C allele showed significantly elevated levels of MIF RNA expression in comparison to individuals with GG genotype. Conclusion: MIF variant could be considered as a factor making female patients with T2DM vulnerable to depression. So, this might be an important result for precise diagnosis and/or earlier treatment. © 2019 Elsevier Ltd

Style	Citing Format
MLA	Hamidi AK, et al.. "Mif 173 G>C Variation Was Associated With Depressive Disorder in Type 2 Diabetes in an Iranian Population." Psychoneuroendocrinology, vol. 104, no. , 2019, pp. 243-248.
APA	Hamidi AK, Arzaghi SM, Qorbani M, Khatami F, Ebrahimi M, Bandarian F, Enayati S, Amoli MM (2019). Mif 173 G>C Variation Was Associated With Depressive Disorder in Type 2 Diabetes in an Iranian Population. Psychoneuroendocrinology, 104(), 243-248.
Chicago	Hamidi AK, Arzaghi SM, Qorbani M, Khatami F, Ebrahimi M, Bandarian F, Enayati S, Amoli MM. "Mif 173 G>C Variation Was Associated With Depressive Disorder in Type 2 Diabetes in an Iranian Population." Psychoneuroendocrinology 104, no. (2019): 243-248.
Harvard	Hamidi AK et al. (2019) 'Mif 173 G>C Variation Was Associated With Depressive Disorder in Type 2 Diabetes in an Iranian Population', Psychoneuroendocrinology, 104(), pp. 243-248.
Vancouver	Hamidi AK, Arzaghi SM, Qorbani M, Khatami F, Ebrahimi M, Bandarian F, et al.. Mif 173 G>C Variation Was Associated With Depressive Disorder in Type 2 Diabetes in an Iranian Population. Psychoneuroendocrinology. 2019;104():243-248.
BibTex	@article{ author = {Hamidi AK and Arzaghi SM and Qorbani M and Khatami F and Ebrahimi M and Bandarian F and Enayati S and Amoli MM}, title = {Mif 173 G>C Variation Was Associated With Depressive Disorder in Type 2 Diabetes in an Iranian Population}, journal = {Psychoneuroendocrinology}, volume = {104}, number = {}, pages = {243-248}, year = {2019} }
RIS	TY - JOUR AU - Hamidi AK AU - Arzaghi SM AU - Qorbani M AU - Khatami F AU - Ebrahimi M AU - Bandarian F AU - Enayati S AU - Amoli MM TI - Mif 173 G>C Variation Was Associated With Depressive Disorder in Type 2 Diabetes in an Iranian Population JO - Psychoneuroendocrinology VL - 104 IS - SP - 243 EP - 248 PY - 2019 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract