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Immediate Hypersensitivity Reaction to Levetiracetam: A Case Report Study Publisher Pubmed



Hosseini MS1 ; Namazi S1, 2
Authors
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Authors Affiliations
  1. 1. Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Research Center for Rational Use of Drugs, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: DARU# Journal of Pharmaceutical Sciences Published:2024


Abstract

Background: Anticonvulsant drugs are one of the most common causes of delayed hypersensitivity reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). These reactions are more prevalent with aromatic anticonvulsant drugs such as phenytoin and carbamazepine. However, immediate hypersensitivity reactions such as urticaria, angioedema, and anaphylaxis with anticonvulsant drugs are rare. We describe a 51-year-old woman who developed spreading skin rashes on her wrists with urticaria and pruritus 24 h after receiving intravenous levetiracetam. Conclusion: Clinicians should be aware of immediate hypersensitivity reactions with intravenous levetiracetam. Graphical abstract: (Figure presented.) © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2023.