Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Assessing the Clinical and Biochemical Efficacy of Alpha-Lipoic Acid in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Placebo-Controlled Clinical Trial Publisher



Ebrahimimameghani M1 ; Asghari S2 ; Naeini F2 ; Taghizadeh M2 ; Hamedishahraki S3 ; Amirkhizi F4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Clinical Nutrition, Faculty of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Epidemiology and Biostatistics, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, Iran
  4. 4. Department of Nutrition, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, Iran

Source: Journal of Functional Foods Published:2024


Abstract

Given the importance of inflammatory and metabolic markers in the pathophysiology of non-alcoholic fatty liver disease (NAFLD), this study was designed to evaluate the effects of alpha-lipoic acid (ALA) supplementation on inflammatory and serum levels of fetuin-A, sirtuin1 (SIRT-1), cytokeratin 18 (CK-18), and hepatic steatosis in patients with NAFLD. In a double-blind, placebo-controlled, randomized clinical trial, 50 patients with NAFLD were randomized to receive daily supplementation with either two capsules of ALA (each capsule containing 600 mg ALA plus 400 mg/day of vitamin E) or two placebo capsules (two placebo capsules plus 400 mg/day of vitamin E) for 12 weeks. Significant reductions in homeostasis model assessment for insulin resistance (HOMA-IR) score and serum levels of insulin and fetuin-A were observed in the ALA group compared to the placebo group (all P < 0.05). ALA supplementation was significantly more effective than placebo in reducing hepatic steatosis by at least one grade. © 2024 The Author(s)
Related Docs
View other Related Docs
1. The Effect of Alpha-Lipoic Acid on Liver Function and Metabolic Markers in Obese Patients With Non-Alcoholic Fatty Liver Disease: A Double-Blind Randomized Controlled Trial, Iranian Red Crescent Medical Journal (2018)
2. Unraveling the Link Between Insulin Resistance and Non-Alcoholic Fatty Liver Disease (Or Metabolic Dysfunction-Associated Steatotic Liver Disease): A Narrative Review, Journal of Diabetes and Metabolic Disorders (2023)
3. Evaluation of Mri Proton Density Fat Fraction in Hepatic Steatosis: A Systematic Review and Meta-Analysis, European Radiology (2025)
4. The Clinical Value of Serum Sirtuin-1 Concentration in the Diagnosis of Metabolic Dysfunction-Associated Steatotic Liver Disease, BMC Gastroenterology (2025)
5. The Effect of Soy Isoflavones on Non-Alcoholic Fatty Liver Disease and the Level of Fibroblast Growth Factor-21 and Fetuin A, Scientific Reports (2024)
6. Alpha-Lipoic Acid Supplement in Obesity Treatment: A Systematic Review and Meta-Analysis of Clinical Trials, Clinical Nutrition (2018)
7. Hepatokines: Unveiling the Molecular and Cellular Mechanisms Connecting Hepatic Tissue to Insulin Resistance and Inflammation, Acta Diabetologica (2024)
8. Efficacy and Safety of Oral Alpha-Lipoic Acid Supplementation for Type 2 Diabetes Management: A Systematic Review and Dose– Response Meta-Analysis of Randomized Trials, Endocrine Connections (2022)
Experts (# of related papers)
View all Related Experts
Leila Azadbakht (5)
Bagher Larijani (5)
Other Related Docs
9. Effect of Alpha-Lipoic Acid Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Controlled Clinical Trials, Nutrition (2019)
10. The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-Pla2 Mass and Its Distribution Between Hdl and Apob-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial, Oxidative Medicine and Cellular Longevity (2020)
11. Molecular Mechanisms Involved in Lead Induced Disruption of Hepatic and Pancreatic Glucose Metabolism, Environmental Toxicology and Pharmacology (2015)
12. Prevalence and Correlates of Probable Nonalcoholic Steatohepatitis (Nash) in Pars Cohort Study, Archives of Iranian Medicine (2024)
13. The Role of Dietary Glycemic Index and Glycemic Load in Mediating Genetic Susceptibility Via Mc4r S17782313 Genotypes to Affect Cardiometabolic Risk Factors Among Apparently Healthy Obese Individuals, BioMed Research International (2022)
14. Hesperidin Improves Hepatic Steatosis, Hepatic Enzymes, and Metabolic and Inflammatory Parameters in Patients With Nonalcoholic Fatty Liver Disease: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial, Phytotherapy Research (2019)
15. Green Cardamom Increases Sirtuin-1 and Reduces Inflammation in Overweight or Obese Patients With Non-Alcoholic Fatty Liver Disease: A Double-Blind Randomized Placebo-Controlled Clinical Trial, Nutrition and Metabolism (2018)
16. Flaxseed Supplementation in Non-Alcoholic Fatty Liver Disease: A Pilot Randomized, Open Labeled, Controlled Study, International Journal of Food Sciences and Nutrition (2016)
17. The Association Between Dietary Glycemic Index and Cardio-Metabolic Risk Factors in Obese Individuals, BMC Nutrition (2022)
18. Effects of Naringenin Supplementation in Overweight/Obese Patients With Non-Alcoholic Fatty Liver Disease: Study Protocol for a Randomized Double-Blind Clinical Trial, Trials (2021)
19. The Effect of Alpha-Lipoic Acid (Ala) Supplementation on Cardiovascular Risk Factors in Men With Chronic Spinal Cord Injury: A Clinical Trial, Spinal Cord (2015)
20. Association of the Elderly Dietary Index With Cardiovascular Disease Risk Factors in Elderly Men: A Cross-Sectional Study, Nutrition and Dietetics (2019)
21. Nutrient Patterns in Relation to Insulin Resistance and Endothelial Dysfunction in Iranian Women, Scientific Reports (2024)
22. Emerging Role of Nanotechnology in Treatment of Non-Alcoholic Fatty Liver Disease (Nafld), EXCLI Journal (2023)
23. The Link Between Plant-Based Diet Indices With Biochemical Markers of Bone Turn Over, Inflammation, and Insulin in Iranian Older Adults, Food Science and Nutrition (2021)
24. Effect of Alpha-Lipoic Acid at the Combination With Mefenamic Acid in Girls With Primary Dysmenorrhea: Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Gynecological Endocrinology (2019)
25. Possible Resting Metabolic Rate Modification by the Circulating Rbp4 in Obese Subjects, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2015)
26. Beneficiary Effect of A-Lipoic Acid Supplementation on C-Reactive Protein Level Among Adults: A Systematic Review and Meta-Analysis of Randomized Control Trials, Nutrition and Food Science (2018)
27. Dietary Glycemic Index and Glycemic Load Mediate the Effect of Cartpt Rs2239670 Gene Polymorphism on Metabolic Syndrome and Metabolic Risk Factors Among Adults With Obesity, BMC Endocrine Disorders (2022)
28. The Effects of Gut Microbiome Manipulation on Glycemic Indices in Patients With Non-Alcoholic Fatty Liver Disease: A Comprehensive Umbrella Review, Nutrition and Diabetes (2024)
29. Magnesium Supplementation and Insulin Resistance in Patients With Rheumatoid Arthritis, European Journal of Translational Myology (2022)
30. Healthy Eating Index and Cardiovascular Risk Factors Among Iranian Elderly Individuals, ARYA Atherosclerosis (2017)
31. The Effects of Curcumin Supplementation on Liver Enzymes, Lipid Profile, Glucose Homeostasis, and Hepatic Steatosis and Fibrosis in Patients With Non-Alcoholic Fatty Liver Disease, European Journal of Clinical Nutrition (2019)
32. Effects of Virgin Coconut Oil Consumption on Serum Brain-Derived Neurotrophic Factor Levels and Oxidative Stress Biomarkers in Adults With Metabolic Syndrome: A Randomized Clinical Trial, Nutritional Neuroscience (2024)
33. Dietary Total Antioxidant Capacity Interacts With a Variant of Chromosome 5Q13-14 Locus to Influence Cardio-Metabolic Risk Factors Among Obese Adults, Egyptian Journal of Medical Human Genetics (2022)
34. The Effect of Crocin Supplementation on Glycemic Control, Insulin Resistance and Active Ampk Levels in Patients With Type 2 Diabetes: A Pilot Study, Diabetology and Metabolic Syndrome (2020)
35. Docosahexaenoic Acid-Rich Fish Oil Supplementation Improves Body Composition Without Influence of the Pparγ Pro12ala Polymorphism in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Journal of Nutrigenetics and Nutrigenomics (2016)
36. The Association Between Deficiency of Nutrient Intake and Resting Metabolic Rate in Overweight and Obese Women: A Cross-Sectional Study, BMC Research Notes (2021)
37. Associations Between Dietary Insulin Load With Cardiovascular Risk Factors and Inflammatory Parameters in Elderly Men: A Cross-Sectional Study, British Journal of Nutrition (2019)
38. The Effect of Soy Isoflavones Supplementation on Metabolic Status in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Placebo Controlled Clinical Trial, BMC Public Health (2024)
39. Complex Association of Serum Alanine Aminotransferase With the Risk of Future Cardiovascular Disease in Type 2 Diabetes, Atherosclerosis (2016)
40. Effect of Glutamine Supplementation on Cardiovascular Risk Factors in Patients With Type 2 Diabetes, Nutrition (2015)