Diphenyl-Substituted Triazine Derivatives: Synthesis, Α-Glucosidase Inhibitory Activity, Kinetics and in Silico Studies

Diphenyl-Substituted Triazine Derivatives: Synthesis, Α-Glucosidase Inhibitory Activity, Kinetics and in Silico Studies Publisher Pubmed

Shamim S¹ ; Khan KM^{1, 2} ; Ali M¹ ; Mahdavi M³ ; Salar U⁴ ; Mohammadikhanaposhtani M⁵ ; Faramarzi MA⁶ ; Ullah N⁷ ; Taha M²

Show Affiliations

1. HEJ Research Institute of Chemistry, International Center for Chemical & Biological Sciences, University of Karachi, Karachi, 75270, Pakistan
2. Department of Clinical Pharmacy, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, PO Box 31441, Dammam, Saudi Arabia
3. Endocrinology & Metabolism Research Center, Endocrinology & Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Dr. Panjwani Center for Molecular Medicine & Drug Research, International Center for Chemical & Biological Sciences, University of Karachi, Karachi, 75270, Pakistan
5. Cellular & Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
6. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
7. Chemistry Department, King Fahd University of Petroleum & Minerals, Dhahran, 31261, Saudi Arabia

Source: Future Medicinal Chemistry Published:2023

Abstract

Background: Diabetes mellitus (DM) is a chronic disorder, considered to be a major global health challenge in the 21st century. α-Glucosidase enzyme is a well-known drug target to treat Type II DM. Methods: A new library of biphenyl-substituted triazines was synthesized and confirmed by various spectroscopic techniques. Results: All compounds showed potent α-glucosidase inhibitory activity, with IC50 values ranging from 35.35 ± 0.34 to 564.41 ± 0.91 μM, as the standard acarbose, IC50 value of 750.7 ± 0.13 μM. Our in silico study has predicted key interactions with the enzyme's active site. Drug-likeness and absorption, distribution, metabolism, excretion and toxicity were also studied. Conclusion: This study has identified a range of potential hits against the α-glucosidase enzyme that may serve as antidiabetic agents after further investigations. © 2023 Newlands Press.

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Style	Citing Format
MLA	Shamim S, et al.. "Diphenyl-Substituted Triazine Derivatives: Synthesis, Α-Glucosidase Inhibitory Activity, Kinetics and in Silico Studies." Future Medicinal Chemistry, vol. 15, no. 18, 2023, pp. 1651-1668.
APA	Shamim S, Khan KM, Ali M, Mahdavi M, Salar U, Mohammadikhanaposhtani M, Faramarzi MA, Ullah N, Taha M (2023). Diphenyl-Substituted Triazine Derivatives: Synthesis, Α-Glucosidase Inhibitory Activity, Kinetics and in Silico Studies. Future Medicinal Chemistry, 15(18), 1651-1668.
Chicago	Shamim S, Khan KM, Ali M, Mahdavi M, Salar U, Mohammadikhanaposhtani M, Faramarzi MA, Ullah N, Taha M. "Diphenyl-Substituted Triazine Derivatives: Synthesis, Α-Glucosidase Inhibitory Activity, Kinetics and in Silico Studies." Future Medicinal Chemistry 15, no. 18 (2023): 1651-1668.
Harvard	Shamim S et al. (2023) 'Diphenyl-Substituted Triazine Derivatives: Synthesis, Α-Glucosidase Inhibitory Activity, Kinetics and in Silico Studies', Future Medicinal Chemistry, 15(18), pp. 1651-1668.
Vancouver	Shamim S, Khan KM, Ali M, Mahdavi M, Salar U, Mohammadikhanaposhtani M, et al.. Diphenyl-Substituted Triazine Derivatives: Synthesis, Α-Glucosidase Inhibitory Activity, Kinetics and in Silico Studies. Future Medicinal Chemistry. 2023;15(18):1651-1668.
BibTex	@article{ author = {Shamim S and Khan KM and Ali M and Mahdavi M and Salar U and Mohammadikhanaposhtani M and Faramarzi MA and Ullah N and Taha M}, title = {Diphenyl-Substituted Triazine Derivatives: Synthesis, Α-Glucosidase Inhibitory Activity, Kinetics and in Silico Studies}, journal = {Future Medicinal Chemistry}, volume = {15}, number = {18}, pages = {1651-1668}, year = {2023} }
RIS	TY - JOUR AU - Shamim S AU - Khan KM AU - Ali M AU - Mahdavi M AU - Salar U AU - Mohammadikhanaposhtani M AU - Faramarzi MA AU - Ullah N AU - Taha M TI - Diphenyl-Substituted Triazine Derivatives: Synthesis, Α-Glucosidase Inhibitory Activity, Kinetics and in Silico Studies JO - Future Medicinal Chemistry VL - 15 IS - 18 SP - 1651 EP - 1668 PY - 2023 ER -

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