Transvenous Embolization Versus Surgical Intervention for Csf Venous Fistulas: A Systematic Review and Meta-Analysis Publisher Pubmed



Jazayeri SB ; Eraghi MM ; Ognard J ; Ghozy S ; Kadirvel R ; Brinjikji W ; Kallmes DF
Source: American Journal of Neuroradiology Published:2025

Abstract

BACKGROUND: The efficacy and safety profiles of surgical and embolization techniques for CSF-venous fistulas (CVFs) in patients with spontaneous intracranial hypotension (SIH) are not well-defined because of limited data and a lack of randomized trials. PURPOSE: This systematic review and meta-analysis aims to compare the efficacy and safety of surgical treatment and transvenous embolization for CVFs in patients with SIH. DATA SOURCES: PubMed, Embase, and Scopus were searched from inception to September 2024. STUDY SELECTION: Clinical studies involving adults with confirmed CVFs, treated either surgically or through transvenous embolization, were included. End points analyzed included headache response, overall symptom resolution, radiologic treatment response, and complications. Meta-analyses were performed by using R software, applying random-effects models to calculate prevalence rates and their 95% CIs. Subgroups of surgery and embolization were compared by using the x2 test. The quality of the studies was assessed by using appropriate checklists. DATA ANALYSIS: “Endpoints analyzed included headache response, overall symptom resolution, radiologic treatment response, and complications. Meta-analyses were performed using R software, applying random effects models to calculate prevalence rates and their 95% confidence intervals (CIs). Subgroups of surgery and embolization were compared using Chi-squared test. The quality of the studies was assessed using appropriate checklists.” DATA SYNTHESIS: Fifteen studies involving 321 patients and 354 CVFs were included, all of good quality. Both treatment modalities led to over 90% partial or complete headache response, with no significant difference between embolization (93.9%; 95% CI: 88.3% to 96.9%) and surgery (90.1%; 95% CI: 75.6% to 96.4%) (P = .43). Overall symptom resolution (complete response) was also comparable between embolization (59.1%; 95% CI: 50.5% to 67.1%) and surgery (70.7%; 95% CI: 44.7% to 87.8%) (P = .38). Radiologic response, measured by the Bern score, showed significant improvement postembolization, with no corresponding data from surgical literature. The retreatment/recurrence rate was 14% (95% CI: 9.9% to 19.3%), with no significant difference between embolization (15.3%; 95% CI: 10.3% to 22.1%) and surgery (11.3%; 95% CI: 5.7% to 20.9%) (P = .63). There was no publication bias among the reported end points. LIMITATIONS: Lack of direct comparative effectiveness and small sample sizes heighten the risk of selection and confounding bias. CONCLUSIONS: Our systematic review and meta-analysis indicate that both surgical treatment and transvenous embolization for CVFs in patients with SIH provide comparable efficacy and safety profiles. Future research should employ uniform definitions, standardized radiologic and clinical end points, and long-term follow-up to more rigorously evaluate the relative efficacy and safety of these approaches. © 2025 Elsevier B.V., All rights reserved.