Nmda Receptor Antagonists Attenuate the Proconvulsant Effect of Juvenile Social Isolation in Male Mice

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Nmda Receptor Antagonists Attenuate the Proconvulsant Effect of Juvenile Social Isolation in Male Mice Publisher Pubmed

Amiri S^{1, 2} ; Hajmirzaian A^{1, 2} ; Aminikhoei H^{1, 2} ; Momeny M³ ; Shirzadian A^{1, 2} ; Balaei MR⁴ ; Zarrinrad G³ ; Ghazikhansari M^{1, 2} ; Azizi R¹ ; Dehpour AR^{1, 2} ; Mehr SE^{1, 2}

Show Affiliations

1. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada

Source: Brain Research Bulletin Published:2016

Abstract

Experiencing psychosocial stress in early life, such as social isolation stress (SIS), is known to have negative enduring effects on the development of the brain and behavior. In addition to anxiety and depressive-like behaviors, we previously showed that juvenile SIS increases susceptibility to pentylenetetrazole (PTZ)-induced seizures in mice through enhancing the nitrergic system activity in the hippocampus. In this study, we investigated the possible involvement of N-methyl-d-aspartate (NMDA) receptors in proconvulsant effects of juvenile SIS. Applying 4 weeks of SIS to juvenile male mice at postnatal day 21-23, we observed an increased susceptibility to PTZ as well as anxiety and depressive-like behaviors in adult mice. Intraperitoneal (i.p.) administration of NMDA receptor antagonists, MK-801 (0.05 mg/kg) and ketamine (0.5 mg/kg), reversed the proconvulsant effects of SIS in Isolated (and not social) housed animals. Co-administration of non-effective doses of nitric oxide synthase (NOS) inhibitors, 7NI (25 mg/kg) and L-NAME (10 mg/kg), with NMDA receptor antagonists, MK-801 (0.01 mg/kg) and ketamine (0.1 mg/kg) attenuated the proconvulsant effects of juvenile SIS only in isolated housed mice. Also, using real time RT-PCR, we showed that hippocampal upregulation of NR2B subunit of NMDA receptor may play a critical role in proconvulsant effects of juvenile SIS by dysregulation of NMDA/NO pathway. In conclusion, results of present study revealed that experiencing SIS during adolescence predisposes the co-occurrence of seizure disorders with psychiatric comorbidities and also, alteration of NMDA receptor structure and function in hippocampus plays a role in proconvulsant effects of juvenile SIS through enhancing the NMDA/NO pathway. © 2016 Elsevier Inc.

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Style	Citing Format
MLA	Amiri S, et al.. "Nmda Receptor Antagonists Attenuate the Proconvulsant Effect of Juvenile Social Isolation in Male Mice." Brain Research Bulletin, vol. 121, no. , 2016, pp. 158-168.
APA	Amiri S, Hajmirzaian A, Aminikhoei H, Momeny M, Shirzadian A, Balaei MR, Zarrinrad G, Ghazikhansari M, Azizi R, Dehpour AR, Mehr SE (2016). Nmda Receptor Antagonists Attenuate the Proconvulsant Effect of Juvenile Social Isolation in Male Mice. Brain Research Bulletin, 121(), 158-168.
Chicago	Amiri S, Hajmirzaian A, Aminikhoei H, Momeny M, Shirzadian A, Balaei MR, Zarrinrad G, et al.. "Nmda Receptor Antagonists Attenuate the Proconvulsant Effect of Juvenile Social Isolation in Male Mice." Brain Research Bulletin 121, no. (2016): 158-168.
Harvard	Amiri S et al. (2016) 'Nmda Receptor Antagonists Attenuate the Proconvulsant Effect of Juvenile Social Isolation in Male Mice', Brain Research Bulletin, 121(), pp. 158-168.
Vancouver	Amiri S, Hajmirzaian A, Aminikhoei H, Momeny M, Shirzadian A, Balaei MR, et al.. Nmda Receptor Antagonists Attenuate the Proconvulsant Effect of Juvenile Social Isolation in Male Mice. Brain Research Bulletin. 2016;121():158-168.
BibTex	@article{ author = {Amiri S and Hajmirzaian A and Aminikhoei H and Momeny M and Shirzadian A and Balaei MR and Zarrinrad G and Ghazikhansari M and Azizi R and Dehpour AR and Mehr SE}, title = {Nmda Receptor Antagonists Attenuate the Proconvulsant Effect of Juvenile Social Isolation in Male Mice}, journal = {Brain Research Bulletin}, volume = {121}, number = {}, pages = {158-168}, year = {2016} }
RIS	TY - JOUR AU - Amiri S AU - Hajmirzaian A AU - Aminikhoei H AU - Momeny M AU - Shirzadian A AU - Balaei MR AU - Zarrinrad G AU - Ghazikhansari M AU - Azizi R AU - Dehpour AR AU - Mehr SE TI - Nmda Receptor Antagonists Attenuate the Proconvulsant Effect of Juvenile Social Isolation in Male Mice JO - Brain Research Bulletin VL - 121 IS - SP - 158 EP - 168 PY - 2016 ER -

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