Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Disruption of Blood-Aqueous Barrier in Dry Eye Disease Publisher Pubmed



Aghaei H1 ; Kheirkhah A2 ; Es Haghi A1, 3 ; Reza Aghamirsalim M4 ; Asgari S5 ; Mirzakhan Kordamiri M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Ophthalmology, Long School of Medicine, UT Health San Antonio, San Antonio, TX, United States
  3. 3. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Translational Ophthalmology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran

Source: Ocular Surface Published:2021


Abstract

Purpose: To evaluate level of flare in aqueous humor of dry eye disease (DED) and compare it with normal controls. Methods: In this cross-sectional study, we compared the anterior chamber flare between 28 patients with DED (the DED group) and 27 normal age- and gender-matched controls (the control group). DED group was divided in Sjӧgren's syndrome dry eye (SDE, n = 10) and non- Sjӧgren's syndrome dry eye (non-SDE, n = 18) groups. Results: This study enrolled 55 participants including 28 patients with DED and 27 normal controls. The mean age was 53.4 ± 14.7 years in the DED group and 48.5 ± 14.7 years in the control group (P = 0.086). Mean flare was significantly higher in DED group (12.1 ± 10.2 ph/ms, range 2.7–68.3) compared to the control group (5.0 ± 3.9 ph/ms, range 1.30–30.0, P < 0.001). There was no statistically significant difference in the flare intensity between the Sjӧgren syndrome dry eye (SDE) group (14.5 ± 14.4 ph/ms) and the non-Sjӧgren dry eye (non-SDE) group (10.8 ± 6.9 ph/ms, P = 0.330). A significant correlation was observed between the flare intensity and the ocular surface staining in the SDE group (r = 0.62, P = 0.018). Conclusion: There is a significant increase in aqueous humor flare in patients with DED. Such finding, which is a marker of disruption of blood-aqueous barrier, demonstrates deeper tissue involvement than ocular surface in these patients. © 2020
Related Docs
1. Subclinical Inflammatory Response: Accelerated Versus Standard Corneal Cross-Linking, Ocular Immunology and Inflammation (2019)
2. Confocal Scan, Diagnostics in Ocular Imaging: Cornea# Retina# Glaucoma and Orbit (2020)
3. Do Unilateral Herpetic Stromal Keratitis and Neurotrophic Ulcers Cause Bilateral Dry Eye?, Cornea (2015)
4. The Ocular Surface Status in Individuals Having Long-Term Exposure to Ionizing X-Radiations, Contact Lens and Anterior Eye (2019)
5. Application of Artificial Intelligence in Ophthalmology: An Updated Comprehensive Review, Journal of Ophthalmic and Vision Research (2024)
6. Dry Eye Disease: Emerging Approaches to Disease Analysis and Therapy, Journal of Clinical Medicine (2019)
Experts (# of related papers)
View all Related Experts
Seyed Hesam Hashemian (2)
Amir Rakhshan (1)