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A Novel Nanocomposite Containing Zinc Ferrite Nanoparticles Embedded in Carboxymethylcellulose Hydrogel Plus Carbon Nitride Nanosheets With Multifunctional Bioactivity Publisher



Ganjali F1 ; Gorab MG1 ; Moghim Aliabadi HA2 ; Rahmati S3 ; Cohan RA4 ; Eivazzadehkeihan R4 ; Maleki A1 ; Ghafuri H1 ; Mahdavi M5
Authors
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Authors Affiliations
  1. 1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  2. 2. Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
  3. 3. Protein Chemistry Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Nanobiotechnology Department, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran
  5. 5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: RSC Advances Published:2023


Abstract

A novel and biologically active nanobiocomposite is synthesized based on carbon nitride nanosheet (g-C3N4) based carboxymethylcellulose hydrogels with embedded zinc ferrite nanoparticles. Physical-chemical aspects, morphological properties, and their multifunctional biological properties have been considered in the process of evaluation of the synthesized structure. The hydrogels' compressive strength and compressive modulus are 1.98 ± 0.03 MPa and 3.46 ± 0.05 MPa, respectively. Regarding the biological response, it is shown that the nanobiocomposite is non-toxic and biocompatible, and hemocompatible (with Hu02 cells). In addition, the developed material offers a suitable antibacterial activity for both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). © 2023 The Royal Society of Chemistry.