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Uncovering the Link Between Reproductive Factors and Multiple Sclerosis: A Case-Control Study on Iranian Females Publisher Pubmed



Salehi F1 ; Abdollahpour I2 ; Nedjat S3, 6 ; Sahraian MA4 ; Memari AH5 ; Rahnama M5 ; Mansournia MA3
Authors
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Authors Affiliations
  1. 1. Cohort study Center, Shahrekord University of Medical Sciences, Iran
  2. 2. Department of Epidemiology, School of Public Health, Arak University of Medical Sciences, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Iran
  4. 4. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Iran
  5. 5. Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Iran
  6. 6. Knowledge Utilization Research Center, Tehran University of Medical Science, Iran

Source: Multiple Sclerosis and Related Disorders Published:2018


Abstract

Background: Increase of MS prevalence in females compared to males, especially in reproductive age, highlights the important role of reproductive factors in MS pathology. Objectives: We examined the association between females’ reproductive age-related factors and MS risk. Methods: A case-control study including 399 cases and 541 controls was carried out. The adjusted associations between MS risk and reproductive variables including age at menarche, oral contraceptive pills (OCPs) use history, OCP usage duration and age at first use, history of assisted reproductive technologies (ARTs) use, parity history, age at first childbirth and the number of parities, abortion and exclusive breast feeding > 2 months were assessed. Results: We found protective relationships between MS and older age at menarche (OR = 0.90 {95% CI = 0.82–0.98}), ART use history (OR = 0.45 {95% CI = 0.21–0.99}), older maternal age at first childbirth (OR = 0.94{95% CI = 0.89 − 0.99}) and higher number of parities(OR = 0.61 {95% CI = 0.49 − 0.75), whereas using OCPs was associated with higher risk of developing MS (OR = 1.80 {95% CI = 1.35–2.41}). Conclusions: Links were noted between a number of reproductive factors and risk of MS. © 2018 Elsevier B.V.
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