The Need to Manage Arsenic Contamination in the Food Supply Chain and Processing to Promote Public Health; [نیاز به مدیریت آلودگی آرسنیک در زنجیره تأمین و فرآوری مواد غذایی برای ارتقاء سلامت عمومی] Publisher



Abdollahimajd F ; Arjmand B ; Bandarian F ; Farahani M
Source: Applied Food Biotechnology Published:2026

Abstract

Background and Objective: Long-term exposure to arsenic through food, beyond direct risks (such as skin lesions), causes immune system dysfunction, cardiovascular disease, and reduced cognitive development in children. This research provides a health policy framework based on the results of a study of cellular and molecular changes in human keratinocytes exposed to arsenic. Material and Methods: RNA sequencing of arsenic-exposed HaCaT keratinocytes versus controls was used to identify differentially expressed genes. A protein-protein interaction network was then constructed and a critical subnet was extracted through topological analysis. Results and Conclusion: Overall, integrating gene expression with protein interaction analysis highlighted a core protein subnetwork and revealed possible underlying mechanisms. Here, a health policy framework was built on these findings, emphasizing stricter exposure control and the development of surveillance. This open-access article distributed under the terms of the Creative Commons Attribution Non Commercial 4.0 License (CC BY-NC 4.0). To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.