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Serum Vitamin D Status and Cognitive Function in Iranian Older Adults: Evidence From the Birjand Longitudinal Aging Study Publisher Pubmed



Barmaki O1 ; Mansour A2 ; Moodi M3 ; Mirahmad M2 ; Fakhrzadeh H4 ; Arzaghi M4 ; Khorashadi M3 ; Khodabakhshi H5, 6 ; Esmaeili AA7 ; Sharifzadeh G8 ; Zarban A9 ; Sharifi F4 ; Sajjadijazi SM2
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran
  4. 4. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Gerontology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  6. 6. Iranian Research Center of Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  7. 7. Department of Psychiatry, School of Medicine Medical Toxicology & Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran
  8. 8. Department of Epidemiology and Biostatistics, School of Health, Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran
  9. 9. Department of Clinical Biochemistry, School of Medicine, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

Source: Journal of Nutrition Published:2023


Abstract

Background: There is evidence of the role of vitamin D deficiency in cognitive decline. However, the results of studies regarding the relationship between the reduction of vitamin D concentrations and cognitive impairment are heterogeneous. Objectives: We aimed to answer the question of whether vitamin D deficiency is associated with cognitive decline in older adults. Methods: In this cross-sectional study, the baseline data of the Birjand Longitudinal Aging Study (BLAS) were analyzed. Of 1420 participants in the BLAS, 1219 participants aged ≥60 y old were included in the present study. Serum concentrations of 25-hydroxyvitamin D [25(OH)D] were measured by the enzyme-linked immunosorbent assay method. The 6-item Cognitive Impairment Test (6-CIT), Mini-Mental State Examination (MMSE), Category Fluency Test (CFT), and Abbreviated Mental Test Score (AMTS) were used to assess cognitive function. Multiple logistic regression analysis, adjusted for potential confounders, was employed to estimate the association between cognitive function and 25(OH)D concentrations. Results: Among study participants, 905 (74.24%) had sufficient vitamin D concentrations (≥20 ng/ml), 209 (17.15%) had insufficient vitamin D concentrations (12–20 ng/ml), and 105 (8.61%) had vitamin D deficiency (<12 ng/ml). There was no significant correlation between serum 25(OH)D concentrations and scores of 6-CIT (P = 0.279), AMTS (P = 0.181), MMSE (P = 0.118), and CFT (P = 0.259). Also, the prevalence of cognitive impairment had no significant relationship with vitamin D status. Finally, in the multiple logistic regression analysis, there was no association between the insufficient or deficient concentrations of 25(OH)D and impaired cognitive function both before and after adjustment for various cofounders. Conclusions: The present study found no significant association between vitamin D status and cognitive impairment. © 2023 American Society for Nutrition
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