Colon Cancer Versus Colitis: A Microrna and Gene Expression Analysis Via System Biology Tools

Colon Cancer Versus Colitis: A Microrna and Gene Expression Analysis Via System Biology Tools Publisher

Tajikrostami F ; Farzin AO ; Arjmand B ; Razzaghi Z ; Rezaeitavirani M ; Rezaeitavirani M ; Hatami B

Source: Gastroenterology and Hepatology from Bed to Bench Published:2025

Abstract

Aim: The molecular mechanism of this relationship can be detected that promote the transition from colitis to colon cancer via system biology tools is the main aim of this study. Background: There is a correlation between colitis and associated colon analysis. Methods: The differentially expressed microRNA and gene profiles of samples with colitis and colon cancer are extracted from the Gene Expression Omnibus (GEO) database and assessed using the GEO2R program and the CluePedia plugin of Cytoscape software to identify crucial actors and controlled genes or microRNAs. Results: Analyses revealed microRNA analysis was not suitable tool to detect molecular mechanism of colitis to associated colon cancer in mouse model but the gene expression profile assessment leads to introduce CLASP1, CENPM, KIF18A, PRS7, CENPI, ZWINT, SPC24, and CENPK as the critical genes that promote this transition in fibroblast cells of colon cancer. Conclusion: Regulation of ribosome and kinetochore was suggested as a possible treatment to prevent colitis – colon cancer transition. Copyright © 2025, Gastroenterology and Hepatology From Bed to Bench (GHFBB). This is an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits others to copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Style	Citing Format
MLA	Tajikrostami F, et al.. "Colon Cancer Versus Colitis: A Microrna and Gene Expression Analysis Via System Biology Tools." Gastroenterology and Hepatology from Bed to Bench, vol. 18, no. SI, 2025, pp. 68-75.
APA	Tajikrostami F, Farzin AO, Arjmand B, Razzaghi Z, Rezaeitavirani M, Rezaeitavirani M, Hatami B (2025). Colon Cancer Versus Colitis: A Microrna and Gene Expression Analysis Via System Biology Tools. Gastroenterology and Hepatology from Bed to Bench, 18(SI), 68-75.
Chicago	Tajikrostami F, Farzin AO, Arjmand B, Razzaghi Z, Rezaeitavirani M, Rezaeitavirani M, Hatami B. "Colon Cancer Versus Colitis: A Microrna and Gene Expression Analysis Via System Biology Tools." Gastroenterology and Hepatology from Bed to Bench 18, no. SI (2025): 68-75.
Harvard	Tajikrostami F et al. (2025) 'Colon Cancer Versus Colitis: A Microrna and Gene Expression Analysis Via System Biology Tools', Gastroenterology and Hepatology from Bed to Bench, 18(SI), pp. 68-75.
Vancouver	Tajikrostami F, Farzin AO, Arjmand B, Razzaghi Z, Rezaeitavirani M, Rezaeitavirani M, et al.. Colon Cancer Versus Colitis: A Microrna and Gene Expression Analysis Via System Biology Tools. Gastroenterology and Hepatology from Bed to Bench. 2025;18(SI):68-75.
BibTex	@article{ author = {Tajikrostami F and Farzin AO and Arjmand B and Razzaghi Z and Rezaeitavirani M and Rezaeitavirani M and Hatami B}, title = {Colon Cancer Versus Colitis: A Microrna and Gene Expression Analysis Via System Biology Tools}, journal = {Gastroenterology and Hepatology from Bed to Bench}, volume = {18}, number = {SI}, pages = {68-75}, year = {2025} }
RIS	TY - JOUR AU - Tajikrostami F AU - Farzin AO AU - Arjmand B AU - Razzaghi Z AU - Rezaeitavirani M AU - Rezaeitavirani M AU - Hatami B TI - Colon Cancer Versus Colitis: A Microrna and Gene Expression Analysis Via System Biology Tools JO - Gastroenterology and Hepatology from Bed to Bench VL - 18 IS - SI SP - 68 EP - 75 PY - 2025 ER -

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