Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Inducing Apoptosis in Acute Myeloid Leukemia; Mechanisms and Limitations Publisher



Koolivand Z1, 2 ; Bahreini F3, 4, 5 ; Rayzan E2, 6 ; Rezaei N4, 6, 7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Faculty of Pharmacy and Pharmaceutical Sciences, Islamic Azad University, Tehran Medical Sciences University (IAUTMU), Tehran, Iran
  2. 2. International Hematology/Oncology of Pediatrics Experts (IHOPE), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  4. 4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. Institute of Anatomy, University of Luebeck, Luebeck, Germany
  6. 6. Research Center for Immunodeficiencies (RCID), Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Heliyon Published:2025


Abstract

Acute myeloid leukemia is the expansion of leukemic stem cells which might originate from a stem cell or a progenitor which has acquired self-renewal capacity. An aggregation of leukemic blasts in bone marrow, peripheral blood, and extramedullary tissue will result in acute myeloid leukemia. The main difficulty in treating acute myeloid leukemia is multidrug resistance, leading to treatment failure. This unfortunate phenomenon is practically elevated because of apoptosis inhibition in tumor cells. Two general apoptotic pathways are the Bcl-2 regulated pathway (the intrinsic pathway) and the death receptor pathway. Deficiencies in each of these apoptotic pathways can cause the usual resistance mechanism in this disease. This article reviews and highlights different antiapoptotic pathways, currently-used treatments, and new findings in this field, which may lead to the development of treatment methods for acute myeloid leukemia. © 2024 The Authors
Related Docs
View other Related Docs
1. Non-Coding Rnas in Leukemia Drug Resistance: New Perspectives on Molecular Mechanisms and Signaling Pathways, Annals of Hematology (2024)
2. Mitochondrial Targeted Peptides for Cancer Therapy, Tumor Biology (2015)
3. A Comprehensive Insight Into Apoptosis: Molecular Mechanisms, Signaling Pathways, and Modulating Therapeutics, Cancer Investigation (2025)
4. Melatonin As a Regulator of Apoptosis in Leukaemia: Molecular Mechanism and Therapeutic Perspectives, Frontiers in Pharmacology (2023)
5. In Vitro Anticancer Activity of Scrophularia Amplexicaulis Extracts on Mcf-7 and Wehi-164 Cell Line, EXCLI Journal (2020)
6. Metabolically Healthy/Unhealthy Obesity and Breast Cancer: A Possible Role of Plasma-Derived Extracellular Vesicles on the Cancerous Behavior of Triple-Negative Breast Cancer, Biochemical and Biophysical Research Communications (2024)
7. Anti-Proliferative and Apoptotic Effects of Valproic Acid on Hela Cells, International Journal of Cancer Management (2022)
8. Novel Car T Therapy Is a Ray of Hope in the Treatment of Seriously Ill Aml Patients, Stem Cell Research and Therapy (2021)
Experts (# of related papers)
View all Related Experts
Fatemeh Atyabi (2)
Nima Rezaei (1)
Other Related Docs
9. Reinforcing the Primary Immunotherapy Modulators Against Acute Leukemia; Monoclonal Antibodies in Aml, Immunotherapy (2019)
10. The Importance of the Circrna/Wnt Axis in Gliomas: Biological Functions and Clinical Opportunities, Pathology Research and Practice (2024)
11. Combination Therapy of Macromolecules and Small Molecules: Approaches, Advantages, and Limitations, Nanostructures for Cancer Therapy (2017)
12. Anti-Tumor Activity of Cediranib, a Pan-Vascular Endothelial Growth Factor Receptor Inhibitor, in Pancreatic Ductal Adenocarcinoma Cells, Cellular Oncology (2020)
13. Mutational Screening of Rtk-Braf Genes in De Novo Adult Acute Myeloid Leukemia, Gene Reports (2020)
14. Regulation of Bax/Bcl2 Gene Expression in Breast Cancer Cells by Docetaxel-Loaded Human Serum Albumin Nanoparticles, Medical Oncology (2015)
15. Development of a Bioluminescence Assay for Bir2- Caspase3 Interaction Through Split Luciferase Complementary Assay, Biochemical Engineering Journal (2022)
16. Metal-Based Nanoparticles in Cancer Therapy: Exploring Photodynamic Therapy and Its Interplay With Regulated Cell Death Pathways, International Journal of Pharmaceutics (2024)
17. Epstein-Barr Virus Nuclear Antigen 1 (Ebna1) Increases the Expression Levels of Mdm2 and Mdm4 Genes in Hela Cells: A Review on Mdm2 and Mdm4 Roles in Cancer, BMC Research Notes (2025)