Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis

Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis Publisher Pubmed

Ogishi M^{1, 2} ; Yang R¹ ; Rodriguez R^{3, 4} ; Golec DP⁵ ; Martin E^{3, 4} ; Philippot Q^{4, 6} ; Bohlen J^{4, 6} ; Pelham SJ¹ ; Arias AA^{1, 7, 8} ; Khan T⁹ ; Ata M⁹ ; Ali FA⁹ ; Rozenberg F¹⁰ ; Kong XF¹ Show All Authors

Ogishi M^{1, 2}
Yang R¹
Rodriguez R^{3, 4}
Golec DP⁵
Martin E^{3, 4}
Philippot Q^{4, 6}
Bohlen J^{4, 6}
Pelham SJ¹
Arias AA^{1, 7, 8}
Khan T⁹
Ata M⁹
Ali FA⁹
Rozenberg F¹⁰
Kong XF¹
Chrabieh M^{4, 6}
Laine C^{4, 6}
Lei WT¹
Han JE¹
Seeleuthner Y^{4, 6}
Kaul Z⁵
Jouanguy E^{1, 4, 6}
Beziat V^{4, 6}
Youssefian L^{11, 12}
Vahidnezhad H^{11, 12}
Rao VK¹³
Neven B¹⁴
Fieschi C^{15, 16}
Mansouri D¹⁷
Shahrooei M¹⁸
Pekcan S¹⁹
Alkan G²⁰
Emiroglu M²⁰
Tokgoz H²¹
Uitto J^{11, 12}
Hauck F^{3, 4, 22}
Bustamante J^{1, 4, 6, 23}
Abel L^{1, 4, 6}
Keles S²⁴
Parvaneh N^{25, 26}
Marr N^{9, 27}
Schwartzberg PL⁵
Latour S^{3, 4}
Casanova JL^{1, 4, 6, 28, 29}
Boissondupuis S^{1, 4, 6}

Show Affiliations

1. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, United States
2. The David Rockefeller Graduate Program, Rockefeller University, New York, NY, United States
3. Laboratory of Lymphocyte Activation and Susceptibility to EBV Infection, INSERM UMR1163, Paris, France
4. Imagine Institute, University of Paris Cite, Paris, France
5. Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
6. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France
7. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia
8. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia
9. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar
10. Department of Virology, Cochin Hospital, University of Paris, Paris, France
11. Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Philadelphia, PA, United States
12. Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA, United States
13. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
14. Pediatric Immunology and Hematology Department, Necker Hospital for Sick Children Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France
15. Clinical Immunology Department, Saint Louis Hospital, AP-HP Universite de Paris, Paris, France
16. INSERM UMR1126, Institut de Recherche Saint-Louis, Universite de Paris, Paris, France
17. Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
18. Department of Microbiology and Immunology, Laboratory of Clinical Bacteriology and Mycology, KU Leuven, Leuven, Belgium
19. Department of Pediatric Pulmonology, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey
20. Division of Pediatric Infectious Diseases, Department of Pediatrics, Selcuk University, Faculty of Medicine, Konya, Turkey
21. Department of Pediatric Hematology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey
22. Division of Pediatric Immunology and Rheumatology, Department of Pediatrics, Dr. von Hauner Childrenâ€™s Hospital, University Hospital, Ludwig-Maximilians-Universitat Munchen, Munich, Germany
23. Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France
24. Division of Pediatric Allergy and Immunology, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey
25. Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
26. Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran
27. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar
28. Department of Pediatrics, Necker Hospital for Sick Children, Paris, France
29. Howard Hughes Medical Institute, New York, NY, United States

Source: Journal of Experimental Medicine Published:2023

Abstract

Inborn errors of IFN-γ immunity can underlie tuberculosis (TB). We report three patients from two kindreds without EBV viremia or disease but with severe TB and inherited complete ITK deficiency, a condition associated with severe EBV disease that renders immunological studies challenging. They have CD4+ αβ T lymphocytopenia with a concomitant expansion of CD4−CD8− double-negative (DN) αβ and Vδ2− γδ T lymphocytes, both displaying a unique CD38+CD45RA+T-bet+EOMES− phenotype. Itk-deficient mice recapitulated an expansion of the γδ TandDNαβ T lymphocyte populations in the thymus and spleen, respectively. Moreover, the patients’ T lymphocytes secrete small amounts of IFN-γ in response to TCR crosslinking, mitogens, or forced synapse formation with autologous B lymphocytes. Finally, the patients’ total lymphocytes secrete small amounts of IFN-γ, and CD4+, CD8+,DNαβ T, Vδ2+ γδ T, and MAIT cells display impaired IFN-γ production in response to BCG. Inherited ITK deficiency undermines the development and function of various IFN-γ–producing T cell subsets, thereby underlying TB. © 2022 Ogishi et al.

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Style	Citing Format
MLA	Ogishi M, et al.. "Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis." Journal of Experimental Medicine, vol. 220, no. 1, 2023, pp. -.
APA	Ogishi M, Yang R, Rodriguez R, Golec DP, Martin E, Philippot Q, Bohlen J, Pelham SJ, Arias AA, Khan T, Ata M, Ali FA, Rozenberg F, Kong XF, Chrabieh M, Laine C, Lei WT, Han JE, Seeleuthner Y, ... Boissondupuis S (2023). Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis. Journal of Experimental Medicine, 220(1), -.
Chicago	Ogishi M, Yang R, Rodriguez R, Golec DP, Martin E, Philippot Q, Bohlen J, et al.. "Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis." Journal of Experimental Medicine 220, no. 1 (2023): -.
Harvard	Ogishi M et al. (2023) 'Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis', Journal of Experimental Medicine, 220(1), pp. -.
Vancouver	Ogishi M, Yang R, Rodriguez R, Golec DP, Martin E, Philippot Q, et al.. Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis. Journal of Experimental Medicine. 2023;220(1):-.
BibTex	@article{ author = {Ogishi M and Yang R and Rodriguez R and Golec DP and Martin E and Philippot Q and Bohlen J and Pelham SJ and Arias AA and Khan T and Ata M and Ali FA and Rozenberg F and Kong XF and Chrabieh M and Laine C and Lei WT and Han JE and Seeleuthner Y and Kaul Z and Jouanguy E and Beziat V and Youssefian L and Vahidnezhad H and Rao VK and Neven B and Fieschi C and Mansouri D and Shahrooei M and Pekcan S and Alkan G and Emiroglu M and Tokgoz H and Uitto J and Hauck F and Bustamante J and Abel L and Keles S and Parvaneh N and Marr N and Schwartzberg PL and Latour S and Casanova JL and Boissondupuis S}, title = {Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis}, journal = {Journal of Experimental Medicine}, volume = {220}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Ogishi M AU - Yang R AU - Rodriguez R AU - Golec DP AU - Martin E AU - Philippot Q AU - Bohlen J AU - Pelham SJ AU - Arias AA AU - Khan T AU - Ata M AU - Ali FA AU - Rozenberg F AU - Kong XF AU - Chrabieh M AU - Laine C AU - Lei WT AU - Han JE AU - Seeleuthner Y AU - Kaul Z AU - Jouanguy E AU - Beziat V AU - Youssefian L AU - Vahidnezhad H AU - Rao VK AU - Neven B AU - Fieschi C AU - Mansouri D AU - Shahrooei M AU - Pekcan S AU - Alkan G AU - Emiroglu M AU - Tokgoz H AU - Uitto J AU - Hauck F AU - Bustamante J AU - Abel L AU - Keles S AU - Parvaneh N AU - Marr N AU - Schwartzberg PL AU - Latour S AU - Casanova JL AU - Boissondupuis S TI - Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis JO - Journal of Experimental Medicine VL - 220 IS - 1 SP - EP - PY - 2023 ER -

Style

Citing Format

MLA

Ogishi M, et al.. "Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis." Journal of Experimental Medicine, vol. 220, no. 1, 2023, pp. -.

APA

Ogishi M, Yang R, Rodriguez R, Golec DP, Martin E, Philippot Q, Bohlen J, Pelham SJ, Arias AA, Khan T, Ata M, Ali FA, Rozenberg F, Kong XF, Chrabieh M, Laine C, Lei WT, Han JE, Seeleuthner Y, ... Boissondupuis S (2023). Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis. Journal of Experimental Medicine, 220(1), -.

Chicago

Ogishi M, Yang R, Rodriguez R, Golec DP, Martin E, Philippot Q, Bohlen J, et al.. "Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis." Journal of Experimental Medicine 220, no. 1 (2023): -.

Harvard

Ogishi M et al. (2023) 'Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis', Journal of Experimental Medicine, 220(1), pp. -.

Vancouver

Ogishi M, Yang R, Rodriguez R, Golec DP, Martin E, Philippot Q, et al.. Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis. Journal of Experimental Medicine. 2023;220(1):-.

BibTex

@article{ author = {Ogishi M and Yang R and Rodriguez R and Golec DP and Martin E and Philippot Q and Bohlen J and Pelham SJ and Arias AA and Khan T and Ata M and Ali FA and Rozenberg F and Kong XF and Chrabieh M and Laine C and Lei WT and Han JE and Seeleuthner Y and Kaul Z and Jouanguy E and Beziat V and Youssefian L and Vahidnezhad H and Rao VK and Neven B and Fieschi C and Mansouri D and Shahrooei M and Pekcan S and Alkan G and Emiroglu M and Tokgoz H and Uitto J and Hauck F and Bustamante J and Abel L and Keles S and Parvaneh N and Marr N and Schwartzberg PL and Latour S and Casanova JL and Boissondupuis S}, title = {Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis}, journal = {Journal of Experimental Medicine}, volume = {220}, number = {1}, pages = {-}, year = {2023} }

RIS

TY - JOUR
AU - Ogishi M
AU - Yang R
AU - Rodriguez R
AU - Golec DP
AU - Martin E
AU - Philippot Q
AU - Bohlen J
AU - Pelham SJ
AU - Arias AA
AU - Khan T
AU - Ata M
AU - Ali FA
AU - Rozenberg F
AU - Kong XF
AU - Chrabieh M
AU - Laine C
AU - Lei WT
AU - Han JE
AU - Seeleuthner Y
AU - Kaul Z
AU - Jouanguy E
AU - Beziat V
AU - Youssefian L
AU - Vahidnezhad H
AU - Rao VK
AU - Neven B
AU - Fieschi C
AU - Mansouri D
AU - Shahrooei M
AU - Pekcan S
AU - Alkan G
AU - Emiroglu M
AU - Tokgoz H
AU - Uitto J
AU - Hauck F
AU - Bustamante J
AU - Abel L
AU - Keles S
AU - Parvaneh N
AU - Marr N
AU - Schwartzberg PL
AU - Latour S
AU - Casanova JL
AU - Boissondupuis S
TI - Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity and Underlies Tuberculosis
JO - Journal of Experimental Medicine
VL - 220
IS - 1
SP -
EP -
PY - 2023
ER -

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Abstract