Application of Polycaprolactone Nanofibers As Patch Graft in Ophthalmology

Application of Polycaprolactone Nanofibers As Patch Graft in Ophthalmology Publisher Pubmed

Hashemi H¹ ; Asgari S¹ ; Shahhoseini S² ; Mahbod M¹ ; Atyabi F³ ; Bakhshandeh H⁴ ; Beheshtnejad AH⁵

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1. Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran
2. Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran
3. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Indian Journal of Ophthalmology Published:2018

Abstract

Purpose: The purpose of the study was to evaluate tissue reaction to polycaprolactone (PCL) nanofiber patches in the cornea, conjunctiva, and anterior chamber (AC) in rabbit eyes and to assess their biocompatibility for use as patch grafts. Methods: Two 100 μ PCL patches were implanted under the conjunctiva and in the corneal stroma of one albino New Zealand rabbit, and pathologic evaluation was done after 3 weeks. In the next step, two PCL patches were implanted; one in the corneal stroma and the other in the AC of two rabbits followed by pathologic evaluation after 3 months. Results: On slit-lamp examination, there was minimum inflammation in all cases. Pathologic examination showed that the contact and probably merging between the host tissue and PCL fibers were achieved with minimal tissue reaction. Conclusion: As a biocompatible material, PCL nanofibers seem to be a promising modality for the repair of different tissue defects including melting, thinning, and perforation. They may also be a suitable material for manufacturing keratoprostheses. © 2018 Indian Journal of Ophthalmology.

Style	Citing Format
MLA	Hashemi H, et al.. "Application of Polycaprolactone Nanofibers As Patch Graft in Ophthalmology." Indian Journal of Ophthalmology, vol. 66, no. 2, 2018, pp. 225-228.
APA	Hashemi H, Asgari S, Shahhoseini S, Mahbod M, Atyabi F, Bakhshandeh H, Beheshtnejad AH (2018). Application of Polycaprolactone Nanofibers As Patch Graft in Ophthalmology. Indian Journal of Ophthalmology, 66(2), 225-228.
Chicago	Hashemi H, Asgari S, Shahhoseini S, Mahbod M, Atyabi F, Bakhshandeh H, Beheshtnejad AH. "Application of Polycaprolactone Nanofibers As Patch Graft in Ophthalmology." Indian Journal of Ophthalmology 66, no. 2 (2018): 225-228.
Harvard	Hashemi H et al. (2018) 'Application of Polycaprolactone Nanofibers As Patch Graft in Ophthalmology', Indian Journal of Ophthalmology, 66(2), pp. 225-228.
Vancouver	Hashemi H, Asgari S, Shahhoseini S, Mahbod M, Atyabi F, Bakhshandeh H, et al.. Application of Polycaprolactone Nanofibers As Patch Graft in Ophthalmology. Indian Journal of Ophthalmology. 2018;66(2):225-228.
BibTex	@article{ author = {Hashemi H and Asgari S and Shahhoseini S and Mahbod M and Atyabi F and Bakhshandeh H and Beheshtnejad AH}, title = {Application of Polycaprolactone Nanofibers As Patch Graft in Ophthalmology}, journal = {Indian Journal of Ophthalmology}, volume = {66}, number = {2}, pages = {225-228}, year = {2018} }
RIS	TY - JOUR AU - Hashemi H AU - Asgari S AU - Shahhoseini S AU - Mahbod M AU - Atyabi F AU - Bakhshandeh H AU - Beheshtnejad AH TI - Application of Polycaprolactone Nanofibers As Patch Graft in Ophthalmology JO - Indian Journal of Ophthalmology VL - 66 IS - 2 SP - 225 EP - 228 PY - 2018 ER -

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