Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Curcumin Can Be Acts As Effective Agent for Prevent or Treatment of Alcohol-Induced Toxicity in Hepatocytes: An Illustrated Mechanistic Review Publisher



Salehi E1 ; Mashayekh M1 ; Taheri F2 ; Gholami M3 ; Motaghinejad M2 ; Safari S2 ; Sepehr A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University (IUAPS), Tehran, Iran
  2. 2. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pharmaceutical Research Published:2021


Abstract

Previous studies have shown that alcohol abuse can cause serious liver damage and cirrhosis. The main pathway for these types of hepatocellular cell neurodegeneration is mitochondrial dysfunction, which causes lipid peroxidation and dysfunction of the glutathione ring and the defect of antioxidant enzymes in alcoholic hepatic cells. Alcohol can also initiate malicious inflammatory pathways and trigger the initiation and activation of intestinal and extrinsic apoptosis pathways in hepatocellular tissues that lead to cirrhosis. Previous studies have shown that curcumin may inhibit lipid peroxidation, glutathione dysfunction and restore antioxidant enzymes. Curcumin also modulates inflammation and the production of alcohol-induced biomarkers. Curcumin has been shown to play a critical role in the survival of alcoholic hepatocellular tissue. It has been shown that curcumin can induce and trigger mitochondrial biogenesis and, by this mechanism, prevent the occurrence of both intrinsic and extrinsic apoptosis pathways in liver cells that have been impaired by alcohol. According to this mechanism, curcumin may protect hepatocellular tissue from alcohol-induced cell degeneration and may therefore survive alcoholic hepatocellular tissue. . Based on these mechanisms, the protective functions of curcumin against alcohol-induced cell degeneration due to oxidative stress, inflammation, and apoptosis events in hepatocellular tissue have been recorded. Hence, in this research, we have attempted to evaluate and analyze the main contribution mechanism of curcumin cell defense properties against alcohol-induced hepatocellular damage, according to previous experimental and clinical studies, and in this way we report findings from major studies. © 2021, Briefland. All rights reserved.
Related Docs
View other Related Docs
1. Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and Pi3/Akt/ Gsk3 or Pi3/Akt/Creb/Bdnf Signaling Pathways, International Journal of Molecular and Cellular Medicine (2020)
2. Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective, Nutrients (2018)
3. Novel Neuroprotective Potential of Crocin in Neurodegenerative Disorders: An Illustrated Mechanistic Review, Neurochemical Research (2020)
4. Curcumin Confers Neuroprotection Against Alcohol-Induced Hippocampal Neurodegeneration Via Creb-Bdnf Pathway in Rats, Biomedicine and Pharmacotherapy (2017)
5. Nano-Curcumin Improves Glucose Indices, Lipids, Inflammation, and Nesfatin in Overweight and Obese Patients With Non-Alcoholic Fatty Liver Disease (Nafld): A Double-Blind Randomized Placebo-Controlled Clinical Trial, Nutrition and Metabolism (2019)
6. Recent Advances in Dietary Supplementation, in Treating Non-Alcoholic Fatty Liver Disease, World Journal of Hepatology (2015)
7. Crocin May Be Useful to Prevent or Treatment of Alcohol Induced Neurodegeneration and Neurobehavioral Sequels Via Modulation of Creb/Bdnf and Akt/Gsk Signaling Pathway, Medical Hypotheses (2019)
8. Nrf2 Regulation by Curcumin: Molecular Aspects for Therapeutic Prospects, Molecules (2022)
Experts (# of related papers)
View all Related Experts
Roja Rahimi (3)
Mohammad Abdollahi (3)
Other Related Docs
9. Effects of Non-Linear Resistance Training and Curcumin Supplementation on the Liver Biochemical Markers Levels and Structure in Older Women With Non-Alcoholic Fatty Liver Disease, Journal of Bodywork and Movement Therapies (2020)
10. Wound Healing Effects of Curcumin: A Short Review, Current Pharmaceutical Biotechnology (2016)
11. Effect of Dietary Supplementation of Nanocurcumin on Oxidant Stability of Broiler Chicken Breast Meat Infected With Eimeria Species, Veterinary Research Forum (2020)
12. Dietary Polyphenols for Atherosclerosis: A Comprehensive Review and Future Perspectives, Critical Reviews in Food Science and Nutrition (2019)
13. Mesoporous Silica Coated Spions Containing Curcumin and Silymarin Intended for Breast Cancer Therapy, DARU# Journal of Pharmaceutical Sciences (2022)
14. Turmeric Effect on Subcutaneous Insulin-Induced Amyloid Mass: An in Vivo Study, Drug and Chemical Toxicology (2017)
15. Pharmacokinetic Changes of Tramadol in Rats With Hepatotoxicity Induced by Ethanol and Acetaminophen in Perfused Rat Liver Model, Alcohol (2019)
16. Curcumin and Melanoma: From Chemistry to Medicine, Nutrition and Cancer (2018)
17. The Synergistic Effects of Ω-3 Fatty Acids and Nano-Curcumin Supplementation on Tumor Necrosis Factor (Tnf)-Α Gene Expression and Serum Level in Migraine Patients, Immunogenetics (2017)
18. The Neuromodulatory Effects of Ω-3 Fatty Acids and Nano-Curcumin on the Cox-2/ Inos Network in Migraines: A Clinical Trial Study From Gene Expression to Clinical Symptoms, Endocrine# Metabolic and Immune Disorders - Drug Targets (2019)
19. Curcumin: A New Candidate for Melanoma Therapy?, International Journal of Cancer (2016)
20. Effect of Curcumin on C-Reactive Protein As a Biomarker of Systemic Inflammation: An Updated Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2022)
21. The Effects of Curcumin Supplementation on Liver Enzymes, Lipid Profile, Glucose Homeostasis, and Hepatic Steatosis and Fibrosis in Patients With Non-Alcoholic Fatty Liver Disease, European Journal of Clinical Nutrition (2019)
22. The Role of Dietary Polyphenols in the Management of Inflammatory Bowel Disease, Current Pharmaceutical Biotechnology (2015)
23. Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds, Frontiers in Chemistry (2022)
24. Turmeric for Treatment of Irritable Bowel Syndrome: A Systematic Review of Population-Based Evidence, Iranian Journal of Public Health (2022)
25. A Review of the Available Remedial Procedures for the Treatment of Fatty Liver Disease, Pakistan Journal of Medical and Health Sciences (2020)
26. The Protective Effects of Curcumin and Curmumin Nanomicelle Against Cirrhotic Cardiomyopathy in Bile Duct-Ligated Rats, Nanomedicine Journal (2020)
27. Effects of Curcumin on Nf-Κb, Ap-1, and Wnt/Β-Catenin Signaling Pathway in Hepatitis B Virus Infection, Journal of Cellular Biochemistry (2018)
28. Radiation-Induced Heart Diseases: Protective Effects of Natural Products, Medicina (Lithuania) (2019)
29. Neuroprotective and Antiapoptotic Effects of Allopregnanolone and Curcumin on Arsenic-Induced Toxicity in Sh-Sy5y Dopaminergic Human Neuroblastoma Cells, Neurophysiology (2020)
30. Curcumin Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Regulating Jnk/Nf-Kb Pathway and Ros Production, Inflammopharmacology (2018)