Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Fournier’S Gangrene in a Neonate With Acute Myeloid Leukemia: A Case Report Publisher



Mosayebi Z1, 2 ; Omidian A2 ; Movahedian AH1, 3 ; Kompani F1, 2 ; Hosseininodeh SS2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Children’s Medical Center, Pediatrics Center of Excellence, Tehran, Iran
  3. 3. Bahrami Children’s Hospital, Tehran, Iran

Source: Iranian Journal of Pediatrics Published:2016


Abstract

Introduction: Fournier’s gangrene is an infective necrotizing fasciitis of external genital and perineal region. Hematologic malignancies and immunocompromised status are predisposing factors. Simultaneous occurrence of Fournier’s gangrene and congenital leukemia in neonates is extremely rare. Case Presentation: We present a case of Fournier’s gangrene in a 4-day-old female infant with a necrotic lesion in perineum and no history of trauma or other predisposing condition. Focusing on high blast percentage in blood cell count she was affected by acute myeloid leukemia (M4 type). Pseudomonas aeruginosa was isolated from the blood and wound culture. She was treated with broad spectrum antibiotics and supportive care. The parents refused chemotherapy and the patient was discharged from hospital. Bleeding and DIC was the cause of death in a local hospital few days later. Conclusions: High index of suspicion is essential for diagnosis and appropriate treatment. Congenital leukemia should be considered in the differential diagnosis of a newborn with clinical features of sepsis and necrotizing fasciitis. © 2016, Growth & Development Research Center.