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Comparison of Helicobacter Pylori Detection Methods: It’S Association With Leukocytosis and Monocytosis Publisher Pubmed



Rahimkhani M1 ; Mordadi A2 ; Kazemian K3 ; Khalili H3
Authors
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Authors Affiliations
  1. 1. Faculty of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Epidemiology, Pasteur Institute, Tehran, Iran
  3. 3. Almahdi Clinic, Tehran University of Medical Sciences, Tehran, Iran

Source: Infectious Disorders - Drug Targets Published:2020


Abstract

Background: Helicobacter pylori is a slow-growing micro-aerophilic gram-negative organism found in the stomach and duodenum. It is also associated with a number of stomach-duode-nal diseases. Material and Methods: There are invasive and non-invasive methods to detect Helicobacter pylori infections. In a 13-months period, 101 patients with clinical signs of infection confirmed by biopsy and Rapid Urease test as well as a culture were included in this study. Results: There were significant correlations between breath urease test, anti-Helicobacter pylori serum IgG and IgA as well as fecal Helicobacter pylori Ag with the gold-standard method, (P=0.001) Moreover, there was a significant correlation between Monocytosis (P= 0.05) and gold-standard method. Conclusion: Based on studies conducted on patients with Helicobacter pylori infection, noninva-sive diagnostics methods can be useful in the diagnosis of Helicobacter infections rather than evaluating anti-Helicobacter pylori serum IgM and also increased blood monocytes could be a reliable confirmation for detection. Furthermore, Monocytosis must be considered as a Helicobacter pylori infection at the first step in an area with a high infected percentage. © 2020 Bentham Science Publishers.