Enhancing Fat Grafting: Does the Addition of Hyaluronan Hybrid Cooperative Complexes (Profhilo®) Improve Long-Term Volumetric Durability in Cheek Augmentation? Publisher



M Akhdar MARWA ; Ah Ehsani Ala H ; A Ehsani AMIRHOUSHANG ; K Balighi KAMRAN ; P Nourmohammadpour PEDRAM ; Mk Mohammadabadi Mina KOOHIAN ; A Fahs AMIN ; R Diab REEM ; A Rostami ANAHITA ; A Rahimnia AMIRHOSSEIN
Source: Iranian Journal of Dermatology Published:2025

Abstract

Background: In recent years, fat transplantation and hyaluronic acid fillers have been widely used to restore volume loss and rebalance facial features. This study aims to compare the volumetric durability of autologous fat transplantation alone with that of autologous fat transplantation combined with hyaluronan hybrid cooperative complexes (Profhilo®) injections. Methods: A randomized controlled pilot study was conducted from July 2020 to March 2021, involving 10 patients, of whom 9 completed the procedure. Patients were randomly assigned to two groups: the first group received autologous fat transplantation with two injections of hyaluronic acid (Profhilo®) using the Bio Aesthetic Points (BAP) technique. In contrast, the second group received only autologous fat transplantation to the cheeks (buccal area). The Wrinkle Severity Rating Scale (WSRS) and the Global Aesthetic Improvement Scale (GAIS) were used for assessment. Two parameters were measured to evaluate efficacy: improvement as assessed by two blinded dermatologists and patient self-assessment through photographs. Participants were evaluated at one and six months after the baseline. Results: The WSRS scores indicated no significant difference between the two groups at baseline. Similarly, the GAIS scores assessed by blinded evaluators revealed no significant difference between the groups at both one and six months post-procedure. However, patients’ self-assessed GAIS scores demonstrated significant improvement at one month, although this significance was not sustained at six months. No serious adverse events were reported in either group. Conclusion: This study did not demonstrate that Profhilo® (hyaluronic acid) enhances the volume durability of autologous fat over a period of six months. © 2025 Elsevier B.V., All rights reserved.