Evaluation of the Acute and Sub-Acute Toxicity of the Black Caraway Seed Essential Oil in Wistar Rats

Evaluation of the Acute and Sub-Acute Toxicity of the Black Caraway Seed Essential Oil in Wistar Rats Publisher

Tabarraei H^{1, 2} ; Hassan J² ; Parvizi MR¹ ; Golshahi H³ ; Keshavarztarikhi H⁴

Show Affiliations

1. AJA University of Medical Science Tehran, Iran
2. Division of Toxicology, Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
4. Division of Pharmacology, Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Source: Toxicology Reports Published:2019

Abstract

The aim of the present study was to evaluate the acute toxicity as lethal dose 50% (LD50) and sub-acute toxicity of the black caraway Bunium persicum (Bioss) seed essential oil in male Wistar rats. The compounds of B. persicum were identified by GC/MS and amount of each compound was evaluated. 21 different compounds were determined in the essential oil and the main components were: carvone, p-cymene, gamma-terpinene, p-cymene-8-ol, limonene, isoterpinolene, and 2-beta pinene. For acute toxicity evaluation, the animals were randomly divided into nine group (n = 6) and received 500, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg seed essential oil, respectively and the LD50 value for black caraway seed essential oil was obtained above 4000 mg/kg body weight. According to data, treatment with the black caraway seed essential oil sub-acute toxicity study attenuated histopathological changes in lung, liver, kidney, testes and spleen tissues and the results of this study show that the black caraway essential oil can not affect the immune and blood system, important enzymes and vital organs of the body. © 2019

Related Docs

1. Upper Normal Limits of Serum Alanine Aminotransferase in Healthy Population: A Systematic Review, Middle East Journal of Digestive Diseases (2020)

Experts (# of related papers)

View all Related Experts

Reza Malekzadeh (1)

Shadi Kolahdoozan (1)

Style	Citing Format
MLA	Tabarraei H, et al.. "Evaluation of the Acute and Sub-Acute Toxicity of the Black Caraway Seed Essential Oil in Wistar Rats." Toxicology Reports, vol. 6, no. , 2019, pp. 869-874.
APA	Tabarraei H, Hassan J, Parvizi MR, Golshahi H, Keshavarztarikhi H (2019). Evaluation of the Acute and Sub-Acute Toxicity of the Black Caraway Seed Essential Oil in Wistar Rats. Toxicology Reports, 6(), 869-874.
Chicago	Tabarraei H, Hassan J, Parvizi MR, Golshahi H, Keshavarztarikhi H. "Evaluation of the Acute and Sub-Acute Toxicity of the Black Caraway Seed Essential Oil in Wistar Rats." Toxicology Reports 6, no. (2019): 869-874.
Harvard	Tabarraei H et al. (2019) 'Evaluation of the Acute and Sub-Acute Toxicity of the Black Caraway Seed Essential Oil in Wistar Rats', Toxicology Reports, 6(), pp. 869-874.
Vancouver	Tabarraei H, Hassan J, Parvizi MR, Golshahi H, Keshavarztarikhi H. Evaluation of the Acute and Sub-Acute Toxicity of the Black Caraway Seed Essential Oil in Wistar Rats. Toxicology Reports. 2019;6():869-874.
BibTex	@article{ author = {Tabarraei H and Hassan J and Parvizi MR and Golshahi H and Keshavarztarikhi H}, title = {Evaluation of the Acute and Sub-Acute Toxicity of the Black Caraway Seed Essential Oil in Wistar Rats}, journal = {Toxicology Reports}, volume = {6}, number = {}, pages = {869-874}, year = {2019} }
RIS	TY - JOUR AU - Tabarraei H AU - Hassan J AU - Parvizi MR AU - Golshahi H AU - Keshavarztarikhi H TI - Evaluation of the Acute and Sub-Acute Toxicity of the Black Caraway Seed Essential Oil in Wistar Rats JO - Toxicology Reports VL - 6 IS - SP - 869 EP - 874 PY - 2019 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract