Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19

Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19 Publisher

Shaseb E^{1, 2} ; Ghaffary S^{2, 3} ; Garjani A² ; Zoghi E⁴ ; Dizaji NM² ; Soltani S² ; Sarbakhsh P⁵ ; Somi MH⁶ ; Valizadeh P⁷ ; Taghizadieh A⁸ ; Faghihdinevari M⁶ ; Varshochi M⁹ ; Naghily B⁹ ; Bayatmakoo Z⁹ Show All Authors

Shaseb E^{1, 2}
Ghaffary S^{2, 3}
Garjani A²
Zoghi E⁴
Dizaji NM²
Soltani S²
Sarbakhsh P⁵
Somi MH⁶
Valizadeh P⁷
Taghizadieh A⁸
Faghihdinevari M⁶
Varshochi M⁹
Naghily B⁹
Bayatmakoo Z⁹
Saleh P⁹
Taghizadeh S⁹
Haghdoost M⁹
Owaysi H⁹
Ghavghani FR⁹
Tarzamni MK¹⁰
Moradi R¹⁰
Azar FJA¹¹
Khiabani SS¹
Ghazanchaei A¹²
Hamedani S²
Hatefi S²

Show Affiliations

1. Department of Pharmacotherapy, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4. Faculty of Pharmacy, Tehran University of Medical Sciences, Tabriz, Iran
5. Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
6. Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
7. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
8. Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
9. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
10. Department of Radiology, Medical Radiation Sciences Research Group, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
11. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
12. Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Advanced Pharmaceutical Bulletin Published:2023

Abstract

Purpose: The aim of the study is to evaluate the effect of metformin in complication improvement of hospitalized patients with COVID-19. Methods: This was a randomized clinical trial that involved 189 patients with confirmed COVID-19 infection. Patients in the intervention group received metformin-500 mg twice daily. Patients who received metformin before admission were excluded from the control group. Patients who were discharged before taking at least 2000 mg of metformin were excluded from the study. Primary outcomes were vital signs, need for ICU admission, need for intubation, and mortality. Results: Data showed that patients with diabetes with previous metformin in their regimen had lower percentages of ICU admission and death in comparison with patients without diabetes (11.3% vs. 26.1% (P = 0.014) and 4.9% vs. 23.9% (P ≤ 0.001), respectively). Admission time characteristics were the same for both groups except for diabetes and hyperlipidemia, which were significantly different between the two groups. Observations of naproxen consumption on endpoints, duration of hospitalization, and the levels of spO2 did not show any significant differences between the intervention and the control group. The adjusted OR for intubation in the intervention group versus the control group was 0.21 [95% CI, 0.04-0.99 (P = 0.047)]. Conclusion: In this trial, metformin consumption had no effect on mortality and ICU admission rates in non-diabetic patients. However, metformin improved COVID-19 complications in diabetic patients who had been receiving metformin prior to COVID-19 infection, and it significantly lowered the intubation rates. © 2023 The Author (s).

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Style	Citing Format
MLA	Shaseb E, et al.. "Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19." Advanced Pharmaceutical Bulletin, vol. 13, no. 3, 2023, pp. 621-626.
APA	Shaseb E, Ghaffary S, Garjani A, Zoghi E, Dizaji NM, Soltani S, Sarbakhsh P, Somi MH, Valizadeh P, Taghizadieh A, Faghihdinevari M, Varshochi M, Naghily B, Bayatmakoo Z, Saleh P, Taghizadeh S, Haghdoost M, Owaysi H, Ghavghani FR, ... Hatefi S (2023). Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19. Advanced Pharmaceutical Bulletin, 13(3), 621-626.
Chicago	Shaseb E, Ghaffary S, Garjani A, Zoghi E, Dizaji NM, Soltani S, Sarbakhsh P, et al.. "Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19." Advanced Pharmaceutical Bulletin 13, no. 3 (2023): 621-626.
Harvard	Shaseb E et al. (2023) 'Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19', Advanced Pharmaceutical Bulletin, 13(3), pp. 621-626.
Vancouver	Shaseb E, Ghaffary S, Garjani A, Zoghi E, Dizaji NM, Soltani S, et al.. Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19. Advanced Pharmaceutical Bulletin. 2023;13(3):621-626.
BibTex	@article{ author = {Shaseb E and Ghaffary S and Garjani A and Zoghi E and Dizaji NM and Soltani S and Sarbakhsh P and Somi MH and Valizadeh P and Taghizadieh A and Faghihdinevari M and Varshochi M and Naghily B and Bayatmakoo Z and Saleh P and Taghizadeh S and Haghdoost M and Owaysi H and Ghavghani FR and Tarzamni MK and Moradi R and Azar FJA and Khiabani SS and Ghazanchaei A and Hamedani S and Hatefi S}, title = {Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19}, journal = {Advanced Pharmaceutical Bulletin}, volume = {13}, number = {3}, pages = {621-626}, year = {2023} }
RIS	TY - JOUR AU - Shaseb E AU - Ghaffary S AU - Garjani A AU - Zoghi E AU - Dizaji NM AU - Soltani S AU - Sarbakhsh P AU - Somi MH AU - Valizadeh P AU - Taghizadieh A AU - Faghihdinevari M AU - Varshochi M AU - Naghily B AU - Bayatmakoo Z AU - Saleh P AU - Taghizadeh S AU - Haghdoost M AU - Owaysi H AU - Ghavghani FR AU - Tarzamni MK AU - Moradi R AU - Azar FJA AU - Khiabani SS AU - Ghazanchaei A AU - Hamedani S AU - Hatefi S TI - Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19 JO - Advanced Pharmaceutical Bulletin VL - 13 IS - 3 SP - 621 EP - 626 PY - 2023 ER -

Style

Citing Format

MLA

Shaseb E, et al.. "Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19." Advanced Pharmaceutical Bulletin, vol. 13, no. 3, 2023, pp. 621-626.

APA

Shaseb E, Ghaffary S, Garjani A, Zoghi E, Dizaji NM, Soltani S, Sarbakhsh P, Somi MH, Valizadeh P, Taghizadieh A, Faghihdinevari M, Varshochi M, Naghily B, Bayatmakoo Z, Saleh P, Taghizadeh S, Haghdoost M, Owaysi H, Ghavghani FR, ... Hatefi S (2023). Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19. Advanced Pharmaceutical Bulletin, 13(3), 621-626.

Chicago

Shaseb E, Ghaffary S, Garjani A, Zoghi E, Dizaji NM, Soltani S, Sarbakhsh P, et al.. "Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19." Advanced Pharmaceutical Bulletin 13, no. 3 (2023): 621-626.

Harvard

Shaseb E et al. (2023) 'Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19', Advanced Pharmaceutical Bulletin, 13(3), pp. 621-626.

Vancouver

Shaseb E, Ghaffary S, Garjani A, Zoghi E, Dizaji NM, Soltani S, et al.. Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19. Advanced Pharmaceutical Bulletin. 2023;13(3):621-626.

BibTex

@article{ author = {Shaseb E and Ghaffary S and Garjani A and Zoghi E and Dizaji NM and Soltani S and Sarbakhsh P and Somi MH and Valizadeh P and Taghizadieh A and Faghihdinevari M and Varshochi M and Naghily B and Bayatmakoo Z and Saleh P and Taghizadeh S and Haghdoost M and Owaysi H and Ghavghani FR and Tarzamni MK and Moradi R and Azar FJA and Khiabani SS and Ghazanchaei A and Hamedani S and Hatefi S}, title = {Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19}, journal = {Advanced Pharmaceutical Bulletin}, volume = {13}, number = {3}, pages = {621-626}, year = {2023} }

RIS

TY - JOUR
AU - Shaseb E
AU - Ghaffary S
AU - Garjani A
AU - Zoghi E
AU - Dizaji NM
AU - Soltani S
AU - Sarbakhsh P
AU - Somi MH
AU - Valizadeh P
AU - Taghizadieh A
AU - Faghihdinevari M
AU - Varshochi M
AU - Naghily B
AU - Bayatmakoo Z
AU - Saleh P
AU - Taghizadeh S
AU - Haghdoost M
AU - Owaysi H
AU - Ghavghani FR
AU - Tarzamni MK
AU - Moradi R
AU - Azar FJA
AU - Khiabani SS
AU - Ghazanchaei A
AU - Hamedani S
AU - Hatefi S
TI - Long and Short-Term Metformin Consumption As a Potential Therapy to Prevent Complications of Covid-19
JO - Advanced Pharmaceutical Bulletin
VL - 13
IS - 3
SP - 621
EP - 626
PY - 2023
ER -

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Abstract