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The Central Role of the Sos Dna Repair System in Antibiotics Resistance: A New Target for a New Infectious Treatment Strategy Publisher Pubmed



Memar MY1, 2, 3 ; Yekani M4, 5 ; Celenza G6 ; Poortahmasebi V1, 7, 8 ; Naghili B1 ; Bellio P6 ; Baghi HB1, 2, 7
Authors
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Authors Affiliations
  1. 1. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  5. 5. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
  6. 6. Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy
  7. 7. Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran

Source: Life Sciences Published:2020


Abstract

Bacteria have a considerable ability and potential to acquire resistance against antimicrobial agents by acting diverse mechanisms such as target modification or overexpression, multidrug transporter systems, and acquisition of drug hydrolyzing enzymes. Studying the mechanisms of bacterial cell physiology is mandatory for the development of novel strategies to control the antimicrobial resistance phenomenon, as well as for the control of infections in clinics. The SOS response is a cellular DNA repair mechanism that has an essential role in the bacterial biologic process involved in resistance to antibiotics. The activation of the SOS network increases the resistance and tolerance of bacteria to stress and, as a consequence, to antimicrobial agents. Therefore, SOS can be an applicable target for the discovery of new antimicrobial drugs. In the present review, we focus on the central role of SOS response in bacterial resistance mechanisms and its potential as a new target for control of resistant pathogens. © 2020