Designing Mucoadhesive Discs Containing Stem Bark Extract of Ziziphus Jujuba Based on Iranian Traditional Documents



Hamedi S¹ ; Shamsardakani MR² ; Sadeghpour O³ ; Amin G² ; Hajighasemali D⁴ ; Orafai H⁵
Source: Iranian Journal of Basic Medical Sciences Published:2016

Abstract

Objective (s): Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease. Materials and Methods: Every discs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitro and in vivo mucoadhesion, drug release, water uptake, and disintegration were carried out. Results: Discs showed excellent mucoadhesion and released high amount of the active ingredients (47%) immediately and completed after approximately the first hour. They had a good adhesion in buccal cavity. Conclusion: This study showed that the kinetics of release of the active substance from the mucoadhesive disc obeyed the zero order kinetic and didn’t follow the fick’s law. The water uptake and dissolution (DS), increased with the passing of time. © 2016, Mashhad University of Medical Sciences. All rights reserved.