Age-Related Obesity and Type 2 Diabetes Dysregulate Neuronal Associated Genes and Proteins in Humans

Age-Related Obesity and Type 2 Diabetes Dysregulate Neuronal Associated Genes and Proteins in Humans Publisher Pubmed

Rahimi M¹ ; Vinciguerra M^{2, 3} ; Daghighi M⁴ ; Ozcan B⁵ ; Akbarkhanzadeh V⁶ ; Sheedfar F⁷ ; Amini M⁸ ; Mazza T⁹ ; Pazienza V³ ; Motazacker MM¹⁰ ; Mahmoudi M^{11, 12} ; De Rooij FWM¹³ ; Sijbrands E¹³ ; Peppelenbosch MP¹⁴ Show All Authors

Rahimi M¹
Vinciguerra M^{2, 3}
Daghighi M⁴
Ozcan B⁵
Akbarkhanzadeh V⁶
Sheedfar F⁷
Amini M⁸
Mazza T⁹
Pazienza V³
Motazacker MM¹⁰
Mahmoudi M^{11, 12}
De Rooij FWM¹³
Sijbrands E¹³
Peppelenbosch MP¹⁴
Rezaee F^{14, 15}

Show Affiliations

1. Faculty of Medical Science, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
2. Institute for Liver and Digestive Health, Division of Medicine, University College London (UCL), London, United Kingdom
3. Gastroenterology Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
4. Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
5. Department of Endocrinology, Erasmus Medical Center, Rotterdam, Netherlands
6. Institute Center-45, Medical Center, University of Amsterdam, Netherlands
7. Department of Physiology, Radboud University, Medical Center, Nijmegen, Netherlands
8. Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
9. Bioinformatics Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
10. Department of Clinical Genetics, Academic Medical Center, Amsterdam, Netherlands
11. Department of Pediatrics, Stanford University, School of Medicine, Stanford, CA, United States
12. Department of Nanotechnology and Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
13. Department of cardiovascular genetics, Metabolism, Erasmus Medical Center, Rotterdam, Netherlands
14. Department of Gastroenterology and Hepatology, Erasmus University Medical Center, University of Rotterdam, Rotterdam, Netherlands
15. Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

Source: Oncotarget Published:2015

Abstract

Despite numerous developed drugs based on glucose metabolism interventions for treatment of age-related diseases such as diabetes neuropathies (DNs), DNs are still increasing in patients with type 1 or type 2 diabetes (T1D, T2D). We aimed to identify novel candidates in adipose tissue (AT) and pancreas with T2D for targeting to develop new drugs for DNs therapy. AT-T2D displayed 15 (e.g. SYT4 up-regulated and VGF down-regulated) and pancreas-T2D showed 10 (e.g. BAG3 up-regulated, VAV3 and APOA1 down-regulated) highly differentially expressed genes with neuronal functions as compared to control tissues. ELISA was blindly performed to measure proteins of 5 most differentially expressed genes in 41 human subjects. SYT4 protein was upregulated, VAV3 and APOA1 were down-regulated, and BAG3 remained unchanged in 1- Obese and 2- Obese-T2D without insulin, VGF protein was higher in these two groups as well as in group 3- Obese-T2D receiving insulin than 4-lean subjects. Interaction networks analysis of these 5 genes showed several metabolic pathways (e.g. lipid metabolism and insulin signaling). Pancreas is a novel site for APOA1 synthesis. VGF is synthesized in AT and could be considered as good diagnostic, and even prognostic, marker for age-induced diseases obesity and T2D. This study provides new targets for rational drugs development for the therapy of age-related DNs.

2. Tissue Resident Macrophages: Key Players in the Pathogenesis of Type 2 Diabetes and Its Complications, Clinica Chimica Acta (2016)

3. Lifestyle Alters Gut-Bacteria Function: Linking Immune Response and Host, Best Practice and Research: Clinical Gastroenterology (2017)

4. Lithium Decreases Streptozocin-Induced Diabetic Neuropathy in Rats by Inhibiting of Adenosine Triphosphate (Atp) Degradation, Acta Medica Iranica (2018)

5. Alpha-Lipoic Acid and Coenzyme Q10 Combination Ameliorates Experimental Diabetic Neuropathy by Modulating Oxidative Stress and Apoptosis, Life Sciences (2019)

Experts (# of related papers)

View all Related Experts

Ahmad Reza Dehpour (2)

Shokoufeh Hassani (2)

Style	Citing Format
MLA	Rahimi M, et al.. "Age-Related Obesity and Type 2 Diabetes Dysregulate Neuronal Associated Genes and Proteins in Humans." Oncotarget, vol. 6, no. 30, 2015, pp. 29818-29832.
APA	Rahimi M, Vinciguerra M, Daghighi M, Ozcan B, Akbarkhanzadeh V, Sheedfar F, Amini M, Mazza T, Pazienza V, Motazacker MM, Mahmoudi M, De Rooij FWM, Sijbrands E, Peppelenbosch MP, Rezaee F (2015). Age-Related Obesity and Type 2 Diabetes Dysregulate Neuronal Associated Genes and Proteins in Humans. Oncotarget, 6(30), 29818-29832.
Chicago	Rahimi M, Vinciguerra M, Daghighi M, Ozcan B, Akbarkhanzadeh V, Sheedfar F, Amini M, et al.. "Age-Related Obesity and Type 2 Diabetes Dysregulate Neuronal Associated Genes and Proteins in Humans." Oncotarget 6, no. 30 (2015): 29818-29832.
Harvard	Rahimi M et al. (2015) 'Age-Related Obesity and Type 2 Diabetes Dysregulate Neuronal Associated Genes and Proteins in Humans', Oncotarget, 6(30), pp. 29818-29832.
Vancouver	Rahimi M, Vinciguerra M, Daghighi M, Ozcan B, Akbarkhanzadeh V, Sheedfar F, et al.. Age-Related Obesity and Type 2 Diabetes Dysregulate Neuronal Associated Genes and Proteins in Humans. Oncotarget. 2015;6(30):29818-29832.
BibTex	@article{ author = {Rahimi M and Vinciguerra M and Daghighi M and Ozcan B and Akbarkhanzadeh V and Sheedfar F and Amini M and Mazza T and Pazienza V and Motazacker MM and Mahmoudi M and De Rooij FWM and Sijbrands E and Peppelenbosch MP and Rezaee F}, title = {Age-Related Obesity and Type 2 Diabetes Dysregulate Neuronal Associated Genes and Proteins in Humans}, journal = {Oncotarget}, volume = {6}, number = {30}, pages = {29818-29832}, year = {2015} }
RIS	TY - JOUR AU - Rahimi M AU - Vinciguerra M AU - Daghighi M AU - Ozcan B AU - Akbarkhanzadeh V AU - Sheedfar F AU - Amini M AU - Mazza T AU - Pazienza V AU - Motazacker MM AU - Mahmoudi M AU - De Rooij FWM AU - Sijbrands E AU - Peppelenbosch MP AU - Rezaee F TI - Age-Related Obesity and Type 2 Diabetes Dysregulate Neuronal Associated Genes and Proteins in Humans JO - Oncotarget VL - 6 IS - 30 SP - 29818 EP - 29832 PY - 2015 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract