Experimental Direct-Contact Transmission of Influenza A/H9n2 Virus in the Guinea Pig Model in Iran

Experimental Direct-Contact Transmission of Influenza A/H9n2 Virus in the Guinea Pig Model in Iran Publisher

Ghabeshi S¹ ; Ebrahimie E^{2, 3} ; Salimi V¹ ; Ghanizadeh A⁴ ; Khodakhah F¹ ; Yavarian J¹ ; Norouzbabaei Z¹ ; Sasani F⁵ ; Rezaie F¹ ; Azad TM¹

Show Affiliations

1. Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2. School of Animal and VeterinarySciences, University of Adelaide, Adelaide, Australia
3. Genomics Research Platform, School of Life Sciences, La Trobe University, Melbourne, VIC, Australia
4. Department of Biotechnology, Razi Vaccine and Serum Research Institute, Karaj, Alborz, Iran
5. Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Source: Future Virology Published:2020

Abstract

The present study aims to evaluate risk factors for the transmission of A/H9N2 viruses in guinea pig model. Materials & methods: Lung tissue samples were collected from the chicken clinically infected with influenza A/H9N2 virus in 2018. Next, virus isolation and titration, as well as reverse transcription PCR were performed. Then, hemagglutnation and neuraminidase genes was sequenced to identify different positions (hotspots) involved in transmission and host adaptation. Results: Influenza A/H9N2 virus could replicate in low titers in the nasal turbinate and transmit from infected to noninfected guinea pigs. Conclusion: Hotspots on the surface glycoproteins had the potential to alter transmission properties in the new host. © 2020 Future Medicine Ltd

Style	Citing Format
MLA	Ghabeshi S, et al.. "Experimental Direct-Contact Transmission of Influenza A/H9n2 Virus in the Guinea Pig Model in Iran." Future Virology, vol. 15, no. 5, 2020, pp. 277-292.
APA	Ghabeshi S, Ebrahimie E, Salimi V, Ghanizadeh A, Khodakhah F, Yavarian J, Norouzbabaei Z, Sasani F, Rezaie F, Azad TM (2020). Experimental Direct-Contact Transmission of Influenza A/H9n2 Virus in the Guinea Pig Model in Iran. Future Virology, 15(5), 277-292.
Chicago	Ghabeshi S, Ebrahimie E, Salimi V, Ghanizadeh A, Khodakhah F, Yavarian J, Norouzbabaei Z, Sasani F, Rezaie F, Azad TM. "Experimental Direct-Contact Transmission of Influenza A/H9n2 Virus in the Guinea Pig Model in Iran." Future Virology 15, no. 5 (2020): 277-292.
Harvard	Ghabeshi S et al. (2020) 'Experimental Direct-Contact Transmission of Influenza A/H9n2 Virus in the Guinea Pig Model in Iran', Future Virology, 15(5), pp. 277-292.
Vancouver	Ghabeshi S, Ebrahimie E, Salimi V, Ghanizadeh A, Khodakhah F, Yavarian J, et al.. Experimental Direct-Contact Transmission of Influenza A/H9n2 Virus in the Guinea Pig Model in Iran. Future Virology. 2020;15(5):277-292.
BibTex	@article{ author = {Ghabeshi S and Ebrahimie E and Salimi V and Ghanizadeh A and Khodakhah F and Yavarian J and Norouzbabaei Z and Sasani F and Rezaie F and Azad TM}, title = {Experimental Direct-Contact Transmission of Influenza A/H9n2 Virus in the Guinea Pig Model in Iran}, journal = {Future Virology}, volume = {15}, number = {5}, pages = {277-292}, year = {2020} }
RIS	TY - JOUR AU - Ghabeshi S AU - Ebrahimie E AU - Salimi V AU - Ghanizadeh A AU - Khodakhah F AU - Yavarian J AU - Norouzbabaei Z AU - Sasani F AU - Rezaie F AU - Azad TM TI - Experimental Direct-Contact Transmission of Influenza A/H9n2 Virus in the Guinea Pig Model in Iran JO - Future Virology VL - 15 IS - 5 SP - 277 EP - 292 PY - 2020 ER -

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