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The Formulation and Evaluation of 6-Thioguanine As a Nanostructure Lipid Carrier for the Targeted Delivery of Breast Cancer Publisher



Hashim AA1 ; Altememy D2 ; Mohammad HA3 ; Mahmood HS4 ; Hussein RM1 ; Rezaei M7 ; Khosravian P6
Authors
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Authors Affiliations
  1. 1. Pharmaceutics Department, College of Pharmacy, Ahlal-Bayt University, Karbala, Iraq
  2. 2. Department of Pharmaceutics, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq
  3. 3. Pharmaceutics Department, College of Pharmacy, University of Al-Qadisyiah, Al-Qadisyiah, Iraq
  4. 4. University of Alkafeel–College of Pharmacy, Al-Najaf, Iraq
  5. 5. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Medical Plants Research Centre, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
  7. 7. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Applied Pharmaceutics Published:2024


Abstract

Objective: The main goal was to avoid all the problems associated with usual breast cancer treatment by using 6-thioguanine as a nanostructure lipid carrier (TG-NLCS). This was accomplished by administering an effective and targeted dose of 6-thioguanine (TG) to the tumour site using a long-lasting and biodegradable delivery system. Methods: A combination of heat homogenization and ultrasonication was used to implement the emulsification process. To obtain the optimal formulation, the prepared formulations were first assessed for particle size, Polydispersity Index (PDI), zeta potential, entrapment efficiency, and drug loading capacity. Additionally, a range of physicochemical characterization techniques were employed, including dissolution studies, melting point determination, Fourier-Transform Infrared (FTIR) spectroscopy, and Field Emission Scanning Electron Microscopy (FESEM), as well as cytotoxicity assessment of TG-NLCs in MCF-7 breast cancer cells. Results: The selected formula, TG03, showed a zeta potential of-13.5±0.27 mV and a particle size of 149±0.55 nm. This was further examined using a FESEM. In the in vitro drug release study, the formula demonstrated better-controlled drug release for 48 h in comparison to other formulations. In addition, the significant anti-proliferation activity of TG-NLCs against the MCF-7 breast cancer cell line. Conclusion: Nanostructured lipid carriers (NLCs) are one type of multifunctional nanoparticle that includes many combinations of lipids and medicines for various delivery routes. © 2024 The Authors.
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