Testosterone Reduces Spinal Cord Injury-Induced Effects on Male Reproduction by Preventing Cadm1 Defect

Testosterone Reduces Spinal Cord Injury-Induced Effects on Male Reproduction by Preventing Cadm1 Defect Publisher

Choobineh H^{1, 2} ; Kazemi M³ ; Gilani MAS⁴ ; Heydari T⁵ ; Shokri S⁶ ; Bazrafkan M⁷ ; Hassanzadeh G⁷

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1. School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
2. Zeoonosis Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Anatomy, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Urology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Biology, Islamic Azad University, Parand Branch, Iran
6. Department of Anatomy, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
7. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, P.O. Box: 6447-14155, Tehran, Iran

Source: Cell Journal Published:2018

Abstract

Objective: This study evaluated the effects of exogenous testosterone molecule-1 (CADM1) pathological defect during early and chronic periods of spinal cord injury (SCI). Materials and Methods: In this experimental study, testosterone was administered immediately or after one week of SCI induction. Along with quantification of CADM1 gene expression and its immunoreactivity, we evaluated sperm parameters and serum testosterone level post-SCI. Results: Different grades of abnormalities in sperm parameters and testis architecture were observed along with significant reductions in the level of CADM1 expression and its immunoreactivity in the seminiferous tubules of both acute and chronic SCI groups. Exogenous testosterone, by compensating the serum testosterone level. reduced the percentage of apoptotic and both short head and abnormal sperm froms in the caudal epididymis. Importantly, the beneficial effects of immediate administration of testosterone were prominent. Increases in the level of CADM1 transcription and its immunoreactivity in the testis of SCI mice treated with testosterone were accompanied by improvement of sperm motility as well as testicular Johnsen's and Miller's criteria. Conclusion: Since immediate testosterone treatment improved the immunoreactivity and transcription level of CADM1, the observed beneficial effect of exogenouse testosterone can be attributed to its effect on CADM1 dynamics. © 2018 Royan Institute (ACECR). All Rights Reserved.

2. The Correlation of Gene Expression of Inflammasome Indicators and Impaired Fertility in Rat Model of Spinal Cord Injury: A Time Course Study, Urology Journal (2017)

3. The Effects of Testosterone on Oxidative Stress Markers in Mice With Spinal Cord Injuries, International Journal of Fertility and Sterility (2016)

4. Correlation Between Sperm Dna Fragmentation Index and Cma3 Positive Spermatozoa in Globozoospermic Patients, Andrology (2015)

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Gholamreza Hassanzadeh (3)

Mohammad Ali Sadighi Gilani (3)

Style	Citing Format
MLA	Choobineh H, et al.. "Testosterone Reduces Spinal Cord Injury-Induced Effects on Male Reproduction by Preventing Cadm1 Defect." Cell Journal, vol. 20, no. 2, 2018, pp. 138-149.
APA	Choobineh H, Kazemi M, Gilani MAS, Heydari T, Shokri S, Bazrafkan M, Hassanzadeh G (2018). Testosterone Reduces Spinal Cord Injury-Induced Effects on Male Reproduction by Preventing Cadm1 Defect. Cell Journal, 20(2), 138-149.
Chicago	Choobineh H, Kazemi M, Gilani MAS, Heydari T, Shokri S, Bazrafkan M, Hassanzadeh G. "Testosterone Reduces Spinal Cord Injury-Induced Effects on Male Reproduction by Preventing Cadm1 Defect." Cell Journal 20, no. 2 (2018): 138-149.
Harvard	Choobineh H et al. (2018) 'Testosterone Reduces Spinal Cord Injury-Induced Effects on Male Reproduction by Preventing Cadm1 Defect', Cell Journal, 20(2), pp. 138-149.
Vancouver	Choobineh H, Kazemi M, Gilani MAS, Heydari T, Shokri S, Bazrafkan M, et al.. Testosterone Reduces Spinal Cord Injury-Induced Effects on Male Reproduction by Preventing Cadm1 Defect. Cell Journal. 2018;20(2):138-149.
BibTex	@article{ author = {Choobineh H and Kazemi M and Gilani MAS and Heydari T and Shokri S and Bazrafkan M and Hassanzadeh G}, title = {Testosterone Reduces Spinal Cord Injury-Induced Effects on Male Reproduction by Preventing Cadm1 Defect}, journal = {Cell Journal}, volume = {20}, number = {2}, pages = {138-149}, year = {2018} }
RIS	TY - JOUR AU - Choobineh H AU - Kazemi M AU - Gilani MAS AU - Heydari T AU - Shokri S AU - Bazrafkan M AU - Hassanzadeh G TI - Testosterone Reduces Spinal Cord Injury-Induced Effects on Male Reproduction by Preventing Cadm1 Defect JO - Cell Journal VL - 20 IS - 2 SP - 138 EP - 149 PY - 2018 ER -

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