Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Demographic and Histopathologic Characteristics of Marjolin’S Ulcers in Razi Hospital, Tehran, Iran: A 5-Year Survey



Ehsani AH1, 2 ; Noormohammadpour P1 ; Nasiri N1 ; Faraz PT3 ; Goodarzi A4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Autoimmune Bullous Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Dermatology, Iran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Dermatology Published:2016

Abstract

Background: Approximately 0.77% to 2% of cutaneous ulcers and post-burn scars will develop malignant degeneration. When squamous cell carcinoma (SCC) emerges in a chronic scar or ulcer, it often is referred to as Marjolin’s ulcer (MU). Methods: This cross-sectional study assessed demographic information and pathological features of MU in Razi Hospital during 2009 to 2014. We reviewed 5150 chronic scar/ulcer cases and found 30 MU cases. Results: Patients had an average age of 59.2±19.9 years. Most cases were males Among 30 cases of MU, well-differential SCC accounted for 43.3% of cases. Moderately-differentiated SCC comprised 13.3% of cases, whereas there was invasive SCC in 10% of MUs. Only 3.3% of patients showed poorly-differentiated SCC and 9 (30%) had undifferentiated SCC. The average latency between burn and malignancy was 32.4±18.5 years In the majority (90%) of cases, the initial injury was a burn. The lower and upper limbs comprised 53.3% and 26.7% of cases, respectively. There was one case with a history of melanoma. Among the 4 measured concurrent risk factors for malignancy, sun exposure was the most prevalent. Conclusion: Since there is a high possibility of SCC formation in burn lesions and other identical lesions, rapid follow-up and appropriate treatment in acute burn lesions is necessary. © 2016 Iranian Society of Dermatology.