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Waterpipe and Cigarette Smoking and Drug and Alcohol Consumption, and the Risk of Primary Progressive Multiple Sclerosis: A Population-Based Case-Control Study Publisher



Mortazavi SH1 ; Naser Moghadasi A1 ; Almasihashiani A2, 3 ; Sahraian MA1 ; Goudarzi H4, 5 ; Eskandarieh S1
Authors
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Authors Affiliations
  1. 1. Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran
  3. 3. Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
  4. 4. Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan
  5. 5. Center for Medical Education and International Relations, Faculty of Medicine, Hokkaido University, Sapporo, Japan

Source: Current Journal of Neurology Published:2023


Abstract

Background: Multiple sclerosis (MS) is a chronic central nervous system disease, and primary progressive multiple sclerosis (PPMS) is one the main types of MS, which has unknown environmental risk factors. The present study was conducted with the aim to identify the association of waterpipe and cigarette smoking, substance abuse, and alcohol consumption with the risk of PPMS development. Methods: A population-based, case-control study was conducted in Tehran, Iran, on 146 PPMS cases and 294 controls. PPMS cases were diagnosed and confirmed by neurologists. Standard random digit dialing was used to select sex-matched healthy control participants from the same source population as the cases. Logistic regression analysis was used to estimate unadjusted and adjusted odds ratios (OR). Results: In total, 440 subjects participated in the study. © 2023 Iranian Neurological Association, and Tehran University of Medical Sciences Published by Tehran University of Medical Sciences.
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