New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies

New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies Publisher

Esfahani EN¹ ; Mohammadikhanaposhtani M² ; Rezaei Z³ ; Valizadeh Y³ ; Rajabnia R⁴ ; Hassankalhori M⁵ ; Bandarian F¹ ; Faramarzi MA^{6, 7} ; Samadi N^{8, 9} ; Amini MR¹ ; Mahdavi M¹ ; Larijani B¹

Show Affiliations

1. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran
5. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
7. Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
8. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
9. Pharmaceutical Quality Assurance Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Research on Chemical Intermediates Published:2019

Abstract

We designed and synthesized a series of new ciprofloxacin–dithiocarbamate–benzyl hybrids 5a–n as potential antibacterial agents. All of the synthesized compounds were screened for in vitro antibacterial activity against four bacterial strains (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa). The antibacterial results indicated that some of the synthesized compounds showed remarkable activity, comparable to their parent drug ciprofloxacin. Among the synthesized compounds, the 4-nitro derivative 5n, exhibited the most antibacterial activity against S. aureus, S. epidermidis, and E. coli. The antibacterial activity of this compound against S. aureus and E. coli was twofold higher than that of its parent ciprofloxacin. Molecular modeling of compound 5n was also investigated in the active site of E. coli DNA gyrase. © 2018, Springer Nature B.V.

Style	Citing Format
MLA	Esfahani EN, et al.. "New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies." Research on Chemical Intermediates, vol. 45, no. 2, 2019, pp. 223-236.
APA	Esfahani EN, Mohammadikhanaposhtani M, Rezaei Z, Valizadeh Y, Rajabnia R, Hassankalhori M, Bandarian F, Faramarzi MA, Samadi N, Amini MR, Mahdavi M, Larijani B (2019). New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies. Research on Chemical Intermediates, 45(2), 223-236.
Chicago	Esfahani EN, Mohammadikhanaposhtani M, Rezaei Z, Valizadeh Y, Rajabnia R, Hassankalhori M, Bandarian F, et al.. "New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies." Research on Chemical Intermediates 45, no. 2 (2019): 223-236.
Harvard	Esfahani EN et al. (2019) 'New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies', Research on Chemical Intermediates, 45(2), pp. 223-236.
Vancouver	Esfahani EN, Mohammadikhanaposhtani M, Rezaei Z, Valizadeh Y, Rajabnia R, Hassankalhori M, et al.. New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies. Research on Chemical Intermediates. 2019;45(2):223-236.
BibTex	@article{ author = {Esfahani EN and Mohammadikhanaposhtani M and Rezaei Z and Valizadeh Y and Rajabnia R and Hassankalhori M and Bandarian F and Faramarzi MA and Samadi N and Amini MR and Mahdavi M and Larijani B}, title = {New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies}, journal = {Research on Chemical Intermediates}, volume = {45}, number = {2}, pages = {223-236}, year = {2019} }
RIS	TY - JOUR AU - Esfahani EN AU - Mohammadikhanaposhtani M AU - Rezaei Z AU - Valizadeh Y AU - Rajabnia R AU - Hassankalhori M AU - Bandarian F AU - Faramarzi MA AU - Samadi N AU - Amini MR AU - Mahdavi M AU - Larijani B TI - New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies JO - Research on Chemical Intermediates VL - 45 IS - 2 SP - 223 EP - 236 PY - 2019 ER -

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