Tehran University of Medical Sciences

Science Communicator Platform

Share By
Arsenic and Weight Loss: At a Crossroad Between Lipogenesis and Lipolysis Publisher Pubmed



Handali S1 ; Rezaei M2
Authors

Source: Journal of Trace Elements in Medicine and Biology Published:2021


Abstract

Arsenic is found in soil, food, water and earth crust. Arsenic exposure is associated with chronic diseases such as cancer, cardiovascular disease as well as diabetes. One of complex effects of arsenic is on weight gain or loss. Involvement of arsenic in both weight loss and gain signaling pathways has previously been reported; however, too little attention has been paid to its weight reducing effect. Animal studies exhibited a role of arsenic in weight loss. In this regard, arsenic interference with endocrine system, leptin and adiponectin hormones as well as thermogenesis is more evidence. Apparently, arsenic-induced weight lossis generally meditated by its interaction with thermogenesis. In this review we have discussed the irregularities in metabolic pathways induced by arsenic that can lead to weight loss. © 2021 Elsevier GmbH
Related Docs
View other Related Docs
1. Increased Urinary Arsenic Concentration in Newly Diagnosed Type 2 Diabetes Mellitus: A Gender-Independent, Smoking-Dependent Exposure Biomarker in Older Adults in Tehran, Environmental Science and Pollution Research (2021)
2. Acetyl-L-Carnitine Attenuates Arsenic-Induced Oxidative Stress and Hippocampal Mitochondrial Dysfunction, Biological Trace Element Research (2018)
3. Arsenic and Type 2 Diabetes: Revealing the Environmental Exposure Relationship Through Effective Factors - a Systematic Review, Results in Engineering (2024)
Experts (# of related papers)
View all Related Experts
Mohammad Abdollahi (3)
Omid Sabzevari (2)
Other Related Docs
4. Azelaic Acid Reduces Arsenic-Induced Toxicity and Inflammation in the Rat Islets of Langerhans, Iranian Journal of Basic Medical Sciences (2025)
5. A High-Fat Diet Exacerbates Arsenic Toxicity in Various Organs. a Systematic Review of Toxicity and Mechanism, Current Research in Toxicology (2025)
6. Assessment of Arsenic-Induced Modifications in the Dna Methylation of Insulin-Related Genes in Rat Pancreatic Islets, Ecotoxicology and Environmental Safety (2020)
7. Epigenetic Mechanisms Underlying the Toxic Effects Associated With Arsenic Exposure and the Development of Diabetes, Food and Chemical Toxicology (2017)
8. Ellagic Acid Mitigates Sodium Arsenite-Induced Renal and Hepatic Toxicity in Male Wistar Rats, Pharmacological Reports (2018)
9. Acetyl-L-Carnitine Attenuates Arsenic-Induced Liver Injury by Abrogation of Mitochondrial Dysfunction, Inflammation, and Apoptosis in Rats, Environmental Toxicology and Pharmacology (2018)
10. Assessment of Global Histone Acetylation in Pediatric and Adolescent Obesity: Correlations With Sirt1 Expression and Metabolic-Inflammatory Profiles, PLoS ONE (2023)
11. Mechanistic View for Toxic Effects of Arsenic on Isolated Rat Kidney and Brain Mitochondria, Biologia (Poland) (2015)
12. A Systematic Review of the Association of Neuregulin 4, a Brown Fat–Enriched Secreted Factor, With Obesity and Related Metabolic Disturbances, Obesity Reviews (2020)
13. The Footprints of Oxidative Stress and Mitochondrial Impairment in Arsenic Trioxide-Induced Testosterone Release Suppression in Pubertal and Mature F1-Male Balb/C Mice Via the Downregulation of 3Β-Hsd, 17Β-Hsd, and Cyp11a Expression, Biological Trace Element Research (2020)
14. Strategies to Reduce the Arsenic Contamination in the Soil-Plant System, Arsenic in Plants: Uptake# Consequences and Remediation Techniques (2022)
15. An Updated Systematic Review and Dose-Response Meta-Analysis on the Relation Between Exposure to Arsenic and Risk of Type 2 Diabetes, Toxicology Letters (2023)
16. The Mechanisms of Arsenic-Induced Ovotoxicity, Ultrastructural Alterations, and Autophagic Related Paths: An Enduring Developmental Study in Folliculogenesis of Mice, Ecotoxicology and Environmental Safety (2020)