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Treatment of Recalcitrant Diabetic Ulcers With Trichloroacetic Acid and Fibroblasts; Case Report



Nilforoushzadeh MA1 ; Jaffary F2 ; Siavash M3 ; Heidari A2 ; Ansari N2 ; Siadat AH2
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Authors Affiliations
  1. 1. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2015

Abstract

Background: Foot ulcer, with a prevalence of 15% in general population, is one of the main complications in patients with diabetes. So far, different therapeutic methods have been provided for the treatment of foot ulcers. When no response to the standard treatment methods is observed, other methods would be applied. Case Report: In this report, we introduce two men with type 2 diabetes mellitus and recalcitrant diabetic foot ulcer who were treated with topical 50% trichloroacetic acid solvent and autologous fibroblasts. The treatment resulted in complete healing of foot ulcers in both patients. Conclusion: Trichloroacetic acid and autologous fibroblast can be considered as therapeutic choice for recalcitrant diabetic foot ulcer. © 2015, Isfahan University of Medical Sciences(IUMS). All Rights Reserved.
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1. Effectiveness of Standard Treatment for Foot Ulcer of Diabetic Patients, Journal of Isfahan Medical School (2015)
2. Combination Therapy of Trichloroacetic Acid, Human Autologous Fibroblast Injection and Fibroblast Seeded Microfibrous Collagen Scaffold As a Novel Treatment for Osteomyelitis Diabetic Foot Ulcer, Journal of Diabetes Investigation (2021)
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Mohammad Ali Nilforoushzadeh (2)