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Expression Analysis of a Panel of Long Non-Coding Rnas (Lncrnas) Revealed Their Potential As Diagnostic Biomarkers in Bladder Cancer Publisher Pubmed



Abdolmaleki F1 ; Ghafouifard S1 ; Taheri M2 ; Mordadi A3 ; Afsharpad M4 ; Varmazyar S5 ; Nazparvar B6 ; Oskooei VK1 ; Omrani MD7
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, Hamadan University of medical science, Hamadan, Iran
  4. 4. Cancer Control Research Center, Cancer Control Foundation, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Anatomy, Legal Medicine Research Center, Tehran, Iran
  7. 7. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Genomics Published:2020


Abstract

Introduction: Long non-coding RNAs (lncRNAs) have fundamental roles in cell migration, proliferation, invasion and metastasis. Methods: In the current study, we evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagnostic power. Results: PV1 was down-regulated in tumor tissues compared with both ANCTs and normal controls (Expression ratios of 0.48 and 0.14; P values of 0.4 and <0.001 respectively). HOTAIR, NEAT1, TUG1 and FAS-AS1 were significantly down-regulated in tumor tissues compared with normal controls (Expression ratios of 0.4, 0.68, 0.54 and 0.11; P values of 0.04, 0.02, 0.02 and <0.001 respectively). Conclusion: Combination of transcript levels of seven lncRNAs improved both sensitivity and specificity values to 100%. The current study shows dysregulation of lncRNAs in bladder cancer and implies their role as diagnostic markers in this malignancy. © 2019
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