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Adverse Reactions in a Large Cohort of Patients With Inborn Errors of Immunity Receiving Intravenous Immunoglobulin Publisher Pubmed



Esmaeilzadeh H1, 2 ; Askarisarvestani A2 ; Hosseini N3 ; Samimi S3, 22 ; Shafiei A4 ; Mahdaviani SA5 ; Eslami N6 ; Chavoshzadeh Z6 ; Fallahi M6 ; Khakbazanfard N6 ; Shabestari MS7 ; Aleyasin S1, 2 ; Nabavizadeh SH1, 2 ; Cheraghi T8 Show All Authors
Authors
  1. Esmaeilzadeh H1, 2
  2. Askarisarvestani A2
  3. Hosseini N3
  4. Samimi S3, 22
  5. Shafiei A4
  6. Mahdaviani SA5
  7. Eslami N6
  8. Chavoshzadeh Z6
  9. Fallahi M6
  10. Khakbazanfard N6
  11. Shabestari MS7
  12. Aleyasin S1, 2
  13. Nabavizadeh SH1, 2
  14. Cheraghi T8
  15. Kalantari A9
  16. Ahmadiafshar A10
  17. Safari M11
  18. Eslamian MH11
  19. Molatefi R12
  20. Shirkani A13
  21. Heidarzadeh Arani M14
  22. Tavakol M15
  23. Bemanian MH16
  24. Arshi S16
  25. Nabavi M16
  26. Shokri S16
  27. Shahhosseini B2
  28. Mortazavi N17
  29. Nakhaei P3
  30. Nazari F3, 22
  31. Fallahpour M16
  32. Ahanchian H18
  33. Moazzen N18
  34. Khoshkhui M18
  35. Motlagh AV19
  36. Aghamohammadi A3, 22
  37. Abolhassani H3, 20, 21, 22
  38. Yazdani R3, 22
  39. Rezaei N3, 22
Show Affiliations
Authors Affiliations
  1. 1. Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Division of Allergy and Clinical Immunology, Pediatrics Department, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Division of Allergy and Clinical Immunology, Department of Pediatrics, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Allergy and Clinical immunology Dept, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Immunology and Allergy, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Department of Pediatrics, 17th Shahrivar Children's Hospital, Guilan University of Medical Sciences, Rasht, Iran
  9. 9. Department of Immunology and Allergy, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
  11. 11. Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran
  12. 12. Department of Pediatrics, Bo-Ali children's Hospital of Ardabil University of Medical Sciences, Ardabil, Iran
  13. 13. Allergy and Clinical Immunology Department, Bushehr University of Medical Science, School of Medicine, Bushehr, Iran
  14. 14. Pediatric Department, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  15. 15. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  16. 16. Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  17. 17. Department of Clinical Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  18. 18. Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  19. 19. Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd, Iran
  20. 20. Division of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden
  21. 21. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden
  22. 22. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Clinical Immunology Published:2021


Abstract

Background: Intravenous immunoglobulins (IVIg) are the major treatment in inborn errors of immunity (IEI) disorders; However, IVIg infusions show some adverse effects. We aimed to assess the adverse reactions of IVIg infusions. Methods: Data of IVIg infusions in IEI patients were collected from 2011 to 2021. Totally, 363 IEI patients received IVIg regularly in Iran entered the study. The adverse reactions are classified regarding their severity and chronicity. Results: 22,667 IVIg infusions were performed in the study. 157 patients (43.2%) and 1349 (5.9%) infusions were associated with at least one type of adverse reaction. The highest rates of adverse reactions were seen in severe combined immunodeficiency. Myalgia, chills, headache, fever, and hypotension were the most frequent adverse effects of IVIg. Conclusion: The reactions affect almost half of the patients mainly in the first infusions which necessitate the close observation of IEI patients receiving IVIg. © 2021 Elsevier Inc.
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