A Primary Intraosseous Rhabdomyosarcoma of Mandible: Report of a Rare Case and Review of Literature

A Primary Intraosseous Rhabdomyosarcoma of Mandible: Report of a Rare Case and Review of Literature Publisher

Mashhadi S¹ ; Garajei A² ; Aminishakib P^{1, 3}

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1. Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Head and Neck Surgical Oncology and Reconstructive Surgery, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
3. Oral and Maxillofacial Pathology Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

Source: Frontiers in Dentistry Published:2025

Abstract

Rhabdomyosarcoma is a rare soft tissue malignant neoplasm with striated muscle differentiation often found in the head and neck region. In our case a 33-year-old man presented with a bulging mass near his right mandibular second molar tooth, identified as a unilocular destructive lesion on an X-ray. An incisional biopsy confirmed rhabdomyosarcoma, leading to a hemi-mandibulectomy. Histopathologic findings showed spindle and rhabdoid cells with positive immunoreactivity to Desmin, myogenin and myoD1. In conclusion, it is crucial to differentiate rhabdomyosarcoma from other more common intraosseous malignancies, and using Desmin staining as part of the initial immunohistochemical panel can aid in the diagnosis process. © 2025 The Authors. Published by Tehran University of Medical Sciences.

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Experts (# of related papers)

Nafiseh Sheykhbahaei (1)

Style	Citing Format
MLA	Mashhadi S, Garajei A, Aminishakib P. "A Primary Intraosseous Rhabdomyosarcoma of Mandible: Report of a Rare Case and Review of Literature." Frontiers in Dentistry, vol. 22, no. , 2025, pp. -.
APA	Mashhadi S, Garajei A, Aminishakib P (2025). A Primary Intraosseous Rhabdomyosarcoma of Mandible: Report of a Rare Case and Review of Literature. Frontiers in Dentistry, 22(), -.
Chicago	Mashhadi S, Garajei A, Aminishakib P. "A Primary Intraosseous Rhabdomyosarcoma of Mandible: Report of a Rare Case and Review of Literature." Frontiers in Dentistry 22, no. (2025): -.
Harvard	Mashhadi S, Garajei A, Aminishakib P (2025) 'A Primary Intraosseous Rhabdomyosarcoma of Mandible: Report of a Rare Case and Review of Literature', Frontiers in Dentistry, 22(), pp. -.
Vancouver	Mashhadi S, Garajei A, Aminishakib P. A Primary Intraosseous Rhabdomyosarcoma of Mandible: Report of a Rare Case and Review of Literature. Frontiers in Dentistry. 2025;22():-.
BibTex	@article{ author = {Mashhadi S and Garajei A and Aminishakib P}, title = {A Primary Intraosseous Rhabdomyosarcoma of Mandible: Report of a Rare Case and Review of Literature}, journal = {Frontiers in Dentistry}, volume = {22}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Mashhadi S AU - Garajei A AU - Aminishakib P TI - A Primary Intraosseous Rhabdomyosarcoma of Mandible: Report of a Rare Case and Review of Literature JO - Frontiers in Dentistry VL - 22 IS - SP - EP - PY - 2025 ER -

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