The Coexistence of Asthma and Common Variable Immunodeficiency in a Patient With Tnfrsf13b Gene Mutation Publisher Pubmed



Ranjbarnejad T ; Salehi M ; Abolhassani H ; Sherkat R ; Sharifi M
Source: Iranian Journal of Allergy, Asthma and Immunology Published:2026

Abstract

Common variable immunodeficiency disorder (CVID) is the most prevalent primary immunodeficiency in adults. Pathogenic mutations of the TNFRSF13B gene were identified in CVID patients and associated with autoimmunity and lymphoproliferation. A study on Swedish children unaffected by CVID has shown that rare variants in the TNFRSF13B gene increase the risk of asthma. To the best of our knowledge, asthma has not been reported in CVID patients with TNFRSF13B gene mutations. We described a patient suffering from asthma and CVID with a heterozygous mutation in the TNFRSF13B gene. According to our findings and previous studies, mutations in the TNFRSF13B gene seem to be possibly associated with the occurrence of asthma in CVID patients. Copyright © 2026 Ranjbarnejad et al.