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Signaling Pathways of Melatonin in Prevention of Liver Disorders Via Suppressing of Oxidative Stress in Cellular Level Publisher



Mohammadi M1 ; Rezaie MJ2 ; Rostamzadeh A3 ; Allahveisi A2 ; Mohammadi HR4 ; Mohammadi F5 ; Moayeri A6
Authors
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Authors Affiliations
  1. 1. Hepatitis Research Center, Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Cellular and Molecular Research Center, Department of Anatomical Sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  3. 3. Department of Anatomy and Neuroscience, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Department of Toxicology and Pharmacology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran

Source: Biomedical and Pharmacology Journal Published:2016


Abstract

Melatonin (MT) (N-acetyl-5-methoxytryptamine) is a lipophilic and hydrophilic indoleamine with various physiologic functions MT presents in all cells and tissues and distributes in all cell compartments. Liver is the only organ of circulating MT metabolism. The roles of MT in various liver pathologies have been extensively studied, and it is believed that oxidative stress (OS) and lipid peroxidation (LPO) are the key causing factors of almost all conditions compromising liver function, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), diabetes, liver fibrosis and cirrhosis. MT improves energy production and reduces apoptosis OS and LPO in liver. MT protects liver against OS through multiple ways: inhibition of inflammatory cytokines, direct scavenge of free radicals, stimulation of antioxidant enzymes, decrease of mitochondrial electron leakage and synergistic function with other classical antioxidants. © 2016, Oriental Scientific Publishing Company. All rights reserved.
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