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Comparison of Psychological Symptoms and Cognitive Functions in Patients Under Maintenance Treatment With Methadone or Buprenorphine, Current Opioid Users and Healthy Subjects Publisher Pubmed



Nikraftar NS1 ; Feyzi YF2 ; Ramzani F3 ; Nikbakhtzadeh M4 ; Amini M5 ; Arezoomandan M6 ; Shiehmorteza M1 ; Arezoomandan R5
Authors
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Authors Affiliations
  1. 1. Department of Clinical Pharmacy, Pharmaceutical Science Branche, Islamic Azad University, Tehran, Iran
  2. 2. Student Research Committee, Addiction Department, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Clinical Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran
  4. 4. Department of Physiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran
  5. 5. Addiction Department, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran
  6. 6. School of Basic Sciences, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran

Source: Asian Journal of Psychiatry Published:2021


Abstract

Methadone and buprenorphine can affect the psychological symptoms and cognitive functioning of substance users. This study aimed to compare psychological symptoms and neuropsychological functioning in methadone maintenance patients (MMP), buprenorphine maintenance patients (BMP), current opioid users, and healthy subjects. One hundred and twenty participants (30 in each group) matched for age, sex, and education completed the Symptom Checklist-90-Revised (SCL-90-R) and a battery of neuropsychological tests including the Wisconsin Card Sorting Test (WCST), Wechsler Memory Scale (WMS-IV), and Stroop Color-Word Test (SCWT) assessing executive functioning, working memory, and attention, respectively. Overall, opioid users showed more severe psychological symptoms compared to healthy subjects. MMP and BMP had intermediate scores in SCL-90-R subscales; however, BMP had fewer severe symptoms compared to the MMP group. In terms of cognitive functioning, healthy subjects and current users demonstrated the best and the worst performance, respectively. Also, BMP outperforms MMP on executive functions and attention. However, the MMP had a better performance in WMS (visual memory). Patients receiving maintenance treatment had fewer psychological symptoms and better cognitive performance compared to opioid users. BMP had a better profile in all psychological symptoms and better performance in executive functions and selective attention compared to the MMP suggesting buprenorphine may be a better choice for the treatment of opioid-dependent patients. © 2021 Elsevier B.V.
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