Real-Time Diagnosis of Sentinel Lymph Nodes Involved to Breast Cancer Based on Ph Sensing Through Lipid Synthesis of Those Cells

Real-Time Diagnosis of Sentinel Lymph Nodes Involved to Breast Cancer Based on Ph Sensing Through Lipid Synthesis of Those Cells Publisher Pubmed

Miripour ZS^{1, 2} ; Aghaee P^{1, 2} ; Abbasvandi F³ ; Hoseinpour P⁴ ; Parniani M³ ; Abdolahad M^{1, 2}

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1. Nano Electronic Center of Excellence, Cancer Electronics Research Center, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, Tehran, 14395/515, Iran
2. Nano Electronic Center of Excellence, Thin Film and Nanoelectronics Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran
3. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. Box 15179/64311, Tehran, Iran
4. Central Lab of Breast Pathobiology, SEPAS Lab, Tehran, Iran

Source: Bioscience Reports Published:2020

Abstract

Lipid synthesis is the recently found metabolism of cancer cells after their metastasis to lymph nodes (LNs). Carbonic acid is the main byproduct of the lipid metabolism in such cells which resulted in acidification of LN ambient. Hence, calibrated pH sensing could be a diagnostic method to find involved LNs. Here, we designed a simple pH sensing method by a syringe containing sterile PBS and embedded by litmus paper to intraoperatively check the pH of LN fluid. Injected phosphate buffer saline (PBS) would homogenize the LN fluid and litmus needle would detect the pH of the LN. We presented an experimental pathological calibration for the pH values in correlation with cancerous states of the LNs. This system named metabolism based metastatic lymph diagnoser (MMLD) could be a real-time noninvasive tool for precise and fast diagnosis of involved LNs. © 2020 The Author(s).

2. Intraoperative Pathologically-Calibrated Diagnosis of Lymph Nodes Involved by Breast Cancer Cells Based on Electrical Impedance Spectroscopy; a Prospective Diagnostic Human Model Study, International Journal of Surgery (2021)

Style	Citing Format
MLA	Miripour ZS, et al.. "Real-Time Diagnosis of Sentinel Lymph Nodes Involved to Breast Cancer Based on Ph Sensing Through Lipid Synthesis of Those Cells." Bioscience Reports, vol. 40, no. 6, 2020, pp. -.
APA	Miripour ZS, Aghaee P, Abbasvandi F, Hoseinpour P, Parniani M, Abdolahad M (2020). Real-Time Diagnosis of Sentinel Lymph Nodes Involved to Breast Cancer Based on Ph Sensing Through Lipid Synthesis of Those Cells. Bioscience Reports, 40(6), -.
Chicago	Miripour ZS, Aghaee P, Abbasvandi F, Hoseinpour P, Parniani M, Abdolahad M. "Real-Time Diagnosis of Sentinel Lymph Nodes Involved to Breast Cancer Based on Ph Sensing Through Lipid Synthesis of Those Cells." Bioscience Reports 40, no. 6 (2020): -.
Harvard	Miripour ZS et al. (2020) 'Real-Time Diagnosis of Sentinel Lymph Nodes Involved to Breast Cancer Based on Ph Sensing Through Lipid Synthesis of Those Cells', Bioscience Reports, 40(6), pp. -.
Vancouver	Miripour ZS, Aghaee P, Abbasvandi F, Hoseinpour P, Parniani M, Abdolahad M. Real-Time Diagnosis of Sentinel Lymph Nodes Involved to Breast Cancer Based on Ph Sensing Through Lipid Synthesis of Those Cells. Bioscience Reports. 2020;40(6):-.
BibTex	@article{ author = {Miripour ZS and Aghaee P and Abbasvandi F and Hoseinpour P and Parniani M and Abdolahad M}, title = {Real-Time Diagnosis of Sentinel Lymph Nodes Involved to Breast Cancer Based on Ph Sensing Through Lipid Synthesis of Those Cells}, journal = {Bioscience Reports}, volume = {40}, number = {6}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Miripour ZS AU - Aghaee P AU - Abbasvandi F AU - Hoseinpour P AU - Parniani M AU - Abdolahad M TI - Real-Time Diagnosis of Sentinel Lymph Nodes Involved to Breast Cancer Based on Ph Sensing Through Lipid Synthesis of Those Cells JO - Bioscience Reports VL - 40 IS - 6 SP - EP - PY - 2020 ER -

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Abstract