A Prospective Randomized Trial of Azithromycin Versus Trimethoprim/Sulfamethoxazole in Treatment of Toxoplasmic Retinochoroiditis Publisher



Lashay A¹ ; Mirshahi A¹ ; Parandin N¹ ; Riazi Esfahani H¹ ; Mazloumi M¹ ; Reza Lashay M¹ ; Johari MK¹ ; Ashrafi E¹ Show Affiliations
Source: Journal of Current Ophthalmology Published:2017

Abstract

Purpose To assess the efficacy of oral azithromycin in the treatment of toxoplasmic retinochoroiditis. Methods A randomized interventional comparative study was conducted on 14 patients with ocular toxoplasmosis who were treated with oral azithromycin and 13 patients who were treated with oral trimethoprim/sulfamethoxazole for 6–12 weeks. The achievement of treatment criteria in the two groups and lesion size reduction were considered as primary outcome measures. Results The resolution of inflammatory activity, decrease in the size of retinochoroidal lesions, and final best corrected visual acuity (BCVA) did not differ between the two treatment groups. The lesion size declined significantly in all patients (P = 0.001). There was no significant difference in the reduction of the size of retinal lesions between the two treatment groups (P = 0.17). Within each group, there was a significant improvement in BCVA after treatment; BCVA increased by 0.24 logMAR in the azithromycin group (P = 0.001) and by 0.3 logMAR in the trimethoprim/sulfamethoxazole group (P = 0.001). Conclusions Drug efficacy in terms of reducing the size of retinal lesions and visual improvement was similar in a regimen of trimethoprim/sulfamethoxazole or azithromycin treatment. Therefore, if confirmed with further studies, therapy with azithromycin seems to be an acceptable alternative for the treatment of ocular toxoplasmosis. © 2017 Iranian Society of Ophthalmology