Involvement of Ppar Receptors in the Anticonvulsant Effects of a Cannabinoid Agonist, Win 55,212-2

Involvement of Ppar Receptors in the Anticonvulsant Effects of a Cannabinoid Agonist, Win 55,212-2 Publisher Pubmed

Payandemehr B^{1, 2} ; Ebrahimi A^{1, 2} ; Gholizadeh R¹ ; Rahimian R¹ ; Varastehmoradi B¹ ; Gooshe M¹ ; Aghaei HN³ ; Mousavizadeh K⁴ ; Dehpour AR¹

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1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Neurosurgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Physiology Research Center and Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry Published:2015

Abstract

Cannabinoid and PPAR receptors show well established interactions in a set of physiological effects. Regarding the seizure-modulating properties of both classes of receptors, the present study aimed to evaluate the roles of the PPAR-gamma, PPAR-alpha and CB1 receptors on the anticonvulsant effects of WIN 55,212-2 (WIN, a non selective cannabinoid agonist).The clonic seizure thresholds after intravenous administration of pentylenetetrazole (PTZ) were assessed in mice weighing 23-30. g.WIN increased the seizure threshold dose dependently. Pretreatment with pioglitazone, as a PPARγ agonist, potentiated the anticonvulsant effects of WIN, while PPARγ antagonist inhibited these anticonvulsant effects partially. On the other hand PPARα antagonist reduced the anticonvulsant effects of WIN significantly. Finally the combination of CB1 antagonist and PPARα antagonist could completely block the anticonvulsant properties of WIN.Taken together, these results show for the first time that a functional interaction exists between cannabinoid and PPAR receptors in the modulation of seizure susceptibility. © 2014.

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Ahmad Reza Dehpour (10)

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Style	Citing Format
MLA	Payandemehr B, et al.. "Involvement of Ppar Receptors in the Anticonvulsant Effects of a Cannabinoid Agonist, Win 55,212-2." Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 57, no. , 2015, pp. 140-145.
APA	Payandemehr B, Ebrahimi A, Gholizadeh R, Rahimian R, Varastehmoradi B, Gooshe M, Aghaei HN, Mousavizadeh K, Dehpour AR (2015). Involvement of Ppar Receptors in the Anticonvulsant Effects of a Cannabinoid Agonist, Win 55,212-2. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 57(), 140-145.
Chicago	Payandemehr B, Ebrahimi A, Gholizadeh R, Rahimian R, Varastehmoradi B, Gooshe M, Aghaei HN, Mousavizadeh K, Dehpour AR. "Involvement of Ppar Receptors in the Anticonvulsant Effects of a Cannabinoid Agonist, Win 55,212-2." Progress in Neuro-Psychopharmacology and Biological Psychiatry 57, no. (2015): 140-145.
Harvard	Payandemehr B et al. (2015) 'Involvement of Ppar Receptors in the Anticonvulsant Effects of a Cannabinoid Agonist, Win 55,212-2', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 57(), pp. 140-145.
Vancouver	Payandemehr B, Ebrahimi A, Gholizadeh R, Rahimian R, Varastehmoradi B, Gooshe M, et al.. Involvement of Ppar Receptors in the Anticonvulsant Effects of a Cannabinoid Agonist, Win 55,212-2. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2015;57():140-145.
BibTex	@article{ author = {Payandemehr B and Ebrahimi A and Gholizadeh R and Rahimian R and Varastehmoradi B and Gooshe M and Aghaei HN and Mousavizadeh K and Dehpour AR}, title = {Involvement of Ppar Receptors in the Anticonvulsant Effects of a Cannabinoid Agonist, Win 55,212-2}, journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry}, volume = {57}, number = {}, pages = {140-145}, year = {2015} }
RIS	TY - JOUR AU - Payandemehr B AU - Ebrahimi A AU - Gholizadeh R AU - Rahimian R AU - Varastehmoradi B AU - Gooshe M AU - Aghaei HN AU - Mousavizadeh K AU - Dehpour AR TI - Involvement of Ppar Receptors in the Anticonvulsant Effects of a Cannabinoid Agonist, Win 55,212-2 JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry VL - 57 IS - SP - 140 EP - 145 PY - 2015 ER -

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