Molecular Epidemiology of Hypervirulent Klebsiella Pneumoniae: A Systematic Review and Meta-Analysis



Sanikhani R¹ ; Moeinirad M² ; Shahcheraghi F¹ ; Lari A³ ; Fereshteh S¹ ; Sepehr A¹ ; Salimi A¹ ; Badmasti F¹
Source: Iranian Journal of Microbiology Published:2021

Abstract

Classical (CKp) and hypervirulent (hvKp) Klebsiella pneumoniae are two different circulating pathotypes. The aim of this study was to assess the prevalence, epidemiology and molecular relatedness of hvKps using a systemic review and me-ta-analysis. The data extracted from Medline, Embase, and Web of Science and finally 14 studies met the eligible criteria. To combine prevalence proportions of all studies, we performed the metaprop command embedded in the Meta package software. Totally, of 1814 K. pneumoniae isolates, 21.7% (394/1814) were hvKp. The molecular typing showed that all hvKp isolates were grouped into 50 different sequence types (STs) of them ST23, ST11, ST65 and ST86 were common. K1, K2 and K64 were dominant capsule serotypes that strongly related to ST23, ST65 and ST11, respectively. It seems that clonal group 23 (CG23) is associated with liver abscess and CG11 related to various clinical sources. © 2021 The Authors. Published by Tehran University of Medical Sciences.