Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Association of Parathyroid Hormone With Serum 25-Hydroxyvitamin During Pregnancy Publisher Pubmed



Kazemian E1, 2 ; Madreseh E3 ; Azizi F2 ; Ashrafivand S4 ; Gargari SS4 ; Mansournia MA3 ; Wagner CL5 ; Amouzegar A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Gynecology & Obstetrics, Shohada Tajrish Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pediatrics, Shawn Jenkins Children's Hospital, Medical University of South Carolina, Charleston, SC, United States

Source: Journal of Nutritional Science Published:2023


Abstract

It is currently debated whether vitamin D requirements during pregnancy differ from those during non-gravid states. In current analyses, we aimed to determine the best model for the association between PTH and serum 25-hydroxyvitamin D (25(OH)D) and the threshold for circulating 25(OH)D at which serum parathyroid hormone (PTH) is suppressed. This multicenter prospective cross-sectional study was conducted on 227 Iranian pregnant women aged 15-45 years in their third trimester of pregnancy. The locally weighted smoothing scatter plot (LOWESS) was used to determine the curvilinear shape of the 25(OH)D/PTH relationship. Linear and non-linear methods were employed to determine the best fit and cut-point for serum 25(OH)D concentration. The median serum 25(OH)D and corresponding serum PTH concentration were 17a 26 (13a 44-23a 08) ng/ml and 19a 46 (15a 08-25a 04) pg/ml in our study population, respectively. The LOWESS curve suggested a non-linear and monotonic with a negative slope relation between PTH (pg/ml) and serum 25(OH)D (ng/ml). The optimal model for the association between PTH and serum 25(OH)D was a one-Term fractional polynomial (FP1) (AIC = 1640a 463). The FP1 analysis identified the 25(OH)D threshold of 12a 48 ng/ml at which serum PTH rapidly rose. The expected degree of PTH stimulation seems to have a linear trend as 25(OH)D falls below 40 ng/ml. 25(OH)D (ng/ml) and PTH (pg/ml) had a non-linear and monotonic relationship with a negative slope. Our data suggest that a 25(OH)D threshold of 12a 48 ng/ml is sufficient for parathyroid hormone suppression, which could be used to screen for deficient individuals. Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society.
Related Docs
1. Effect of Vitamin D Receptor Polymorphisms on Plasma Oxidative Stress and Apoptotic Biomarkers Among Breast Cancer Survivors Supplemented Vitamin D3, European Journal of Cancer Prevention (2020)
2. The National Health Program for Vitamin D Supplementation in a Developing Country, Clinical Nutrition ESPEN (2023)
Experts (# of related papers)
Hamed Pouraram (1)
Mahnaz Khanavi (1)