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A Novel Silica Supported Chitosan/Glutaraldehyde As an Efficient Sorbent in Solid Phase Extraction Coupling With Hplc for the Determination of Penicillin G From Water and Wastewater Samples Publisher



Mahmoudian MH1 ; Fazlzadeh M2, 3 ; Niari MH4, 5 ; Azari A2, 6, 7 ; Lima EC8
Authors
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Authors Affiliations
  1. 1. Research Center for Environmental Pollutants, Qom University of Medical Sciences, Qom, Iran
  2. 2. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Social Determinants of Health Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  4. 4. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Department of Environmental Health Engineering, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Department of Environmental Health Engineering, School of Public Health, Kashan University of Medical Sciences, Kashan, Iran
  7. 7. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Institute of Chemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil

Source: Arabian Journal of Chemistry Published:2020


Abstract

In this study, silica@chitosan-glutaraldehyde (Si@Cs-G) was synthesized as a novel adsorbent for extraction of Penicillin G (PG) from the synthetic and real samples followed by HPLC determination. The synthesized adsorbents were characterized by the scanning electron microscopy (SEM), X-ray diffraction (XRD), fourier transform infrared (FTIR), dynamic light scattering (DLS), transmission electron microscopy (TEM) and nitrogen adsorption–desorption techniques. The factors influencing the extraction efficiency including pH, sorbent dose, extraction time, extraction solvent type and its volume were investigated and optimized. Under the optimal conditions (sorbent dosage: 25 mg, desorption solvent (acetonitrile) with volume of 0.75 mL; pH: 6 and extraction time: 50 min), the Si@Cs-G demonstrated high efficiency and linearity (R2 > 0.999) with the concentration of penicillin G ranging from 1 to 300 μg L−1. Extraction recovery in synthetic samples was 98.977%, with LOD = 0.493 μg L−1, LOQ = 1.638 μg L−1 and RSD < 1.953%. The method was successfully applied for determination of PG in real water samples (tap, river, lake and well water) and wastewater samples (SH and SHB hospital effluent). The obtained relative recoveries were in the range of 91.31% -123.27% with RSD less than 6.34% for all the real samples. The dominant mechanism in the PG adsorption process was involved in the π-π interaction, hydrogen bonding, and electrostatic interaction. © 2020 The Authors
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