Randomized, Double-Blind, Placebo-Controlled Clinical Trial Studying the Effects of Turmeric in Combination With Mefenamic Acid in Patients With Primary Dysmenorrhoea Publisher Pubmed



Hesami S^{1, 5} ; Kavianpour M² ; Rashidi Nooshabadi M³ ; Yousefi M^{4, 5} ; Lalooha F^{4, 5} ; Khadem Haghighian H^{1, 5} Show Affiliations
Source: Journal of Gynecology Obstetrics and Human Reproduction Published:2021

Abstract

Primary dysmenorrhea (PDM) is one of the common complaints in women. This study aimed to assess the effects of turmeric and mefenamic acid and a combination compared with placebo on PDM. This clinical trial was conducted on dormitory students with PDM. Subjects completed the visual analog scale (VAS) before randomization. One hundred twenty-eight patients, randomly assigned to one of following groups: Turmeric group (n = 32), mefenamic acid group (n = 32), turmeric and mefenamic acid group (n = 32), and placebo group (n = 32). Turmeric and mefenamic acid were administrated in 500 mg and 250 mg, respectively. Pain severity was assessed in the baseline and the end line by VAS. Statistical analysis was performed using SPSS software. The combination of turmeric and mefenamic acid, dramatically, alleviated pain in comparison to other groups. Our results illustrated that combination of turmeric and mefenamic acid would be better in pain alleviation in PDM. © 2020 Elsevier Masson SAS